A narrative review of the role of Eph receptors in head and neck squamous cell carcinoma

被引：5

作者：

Al-Jamaei, Aisha A. H. ^{[1
,2
]}

Subramanyam, Ramadugula V. ^{[3
]}

Helder, Marco N. ^{[1
]}

Forouzanfar, Tymour ^{[1
,4
]}

van Der Meij, Erik H. ^{[1
,5
]}

Al-Jamei, Sayida ^{[6
,7
,8
]}

de Visscher, Jan G. A. M. ^{[1
,9
]}

机构：

[1] Acad Ctr Dent Amsterdam ACTA, Dept Oral & Maxillofacial Surg Oral Pathol, AmsterdamUMC locat VUmc, Amsterdam, Netherlands

[2] Al Razi Univ, Dept Oral Surg & Oral Med, Collage Dent, Sanaa, Yemen

[3] KM Shah Dent Coll & Hosp, Dept Oral Pathol, Vadodara, India

[4] Leiden Univ, Dept Oral & Maxillofacial Surg, Med Ctr LUMC, Leiden, Netherlands

[5] Med Ctr Leeuwarden, Dept Oral & Maxillofacial Surg, Leeuwarden, Netherlands

[6] OncoRay Natl Ctr Radiat Res Oncol, Fac Med, Dresden, Germany

[7] Univ Hosp Carl Gustav Carus TU, Dresden, Germany

[8] Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany

[9] Acad Ctr Dent Amsterdam ACTA, Dept Oral & Maxillofacial Surg Oral Pathol, AmsterdamUMC locat VUmc, NL-1007 MB Amsterdam, Netherlands

来源：

ORAL DISEASES | 2024年 / 30卷 / 03期

关键词：

Eph receptors; expression; head and neck cancer; head and neck squamous cell carcinoma; metastasis; targeted therapy; NF-KAPPA-B; SYSTEMIC ANTIBIOTICS; RHEIN; PERIODONTITIS; PHARMACOKINETICS; PATHOGENESIS; CANCER;

D O I：

10.1111/odi.14625

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Tyrosine kinase receptors (TKR) coordinate a variety of pathological processes in head and neck squamous cell carcinoma (HNSCC), and eventually play a role in patient outcomes. In this review, the role of Eph receptors in HNSCC progression and the possibility of targeting these receptors are illustrated. All relevant studies were identified through a comprehensive search of four electronic databases, including PubMed, Scopus, web of science, and Embase till August 2022. EphA2 and EphB4, along with ephrin-B2, were the most extensively studied proteins in this family. However, overexpression of EphB4 and its ligand ephrin-B2 were the only proteins that consistently showed association with a poor outcome, indicating that these proteins might serve as valuable prognostic markers in HNSCC. High expression of EphA3 and EphB4 was found to play a crucial role in radioresistance of HNSCC. EphB4 loss, in particular, was observed to induce an immunosuppression phenotypic HNSCC. Currently, ongoing clinical trials are investigating the benefits of EphB4-ephrin-B2 blockade in combination with standard of care treatment in HNSCC. Further efforts are needed to explore the biological role and behavioral complexity of this family of TKR in HNSCC with great attention to avoid heterogeneity of HNSCC subsites.

引用

页码：833 / 845

页数：13

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