The Emerging Roles of Pyroptosis, Necroptosis, and Ferroptosis in Non-Malignant Dermatoses: A Review

被引：5

作者：

Teng, Yan ^{[1
]}

Xu, Danfeng ^{[1
]}

Yang, Xianhong ^{[1
]}

Tang, Hui ^{[2
]}

Tao, Xiaohua ^{[1
]}

Fan, Yibin ^{[1
]}

Ding, Yang ^{[1
]}

机构：

[1] Hangzhou Med Coll, Affiliated Peoples Hosp, Zhejiang Prov Peoples Hosp, Ctr Plast & Reconstruct Surg,Dept Dermatol, Hangzhou 310014, Peoples R China

[2] Bengbu Med Coll, Grad Sch Clin Med, Bengbu, Peoples R China

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2023年 / 16卷

关键词：

pyroptosis; necroptosis; ferroptosis; molecular mechanisms; non-malignant dermatoses; NLRP1; INFLAMMASOME; CELL-DEATH; MECHANISMS; UBIQUITINATION; ACTIVATION; EXPRESSION; GASDERMINS; CASPASES; NECROSIS; INSIGHT;

D O I：

10.2147/JIR.S409699

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unlike apoptosis, pyroptosis, necroptosis, and ferroptosis are recently identified modes of programmed cell death (PCD) with unique molecular pathways. Increasing evidence has indicated that these PCD modes play a crucial role in the pathogenesis of various non-malignant dermatoses (a group of cutaneous disorders), including infective dermatoses, immune-related dermatoses, allergic dermatoses, benign proliferative dermatoses, etc. Moreover, their molecular mechanisms have been suggested as potential therapeutic targets for the prevention and treatment of these dermatoses. In this article, we aim to review and summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis and their roles in the pathogenesis of some non-malignant dermatoses.

引用

页码：1967 / 1977

页数：11

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