The development of COVID-19 treatment

被引：153

作者：

Yuan, Yongliang ^{[1
]}

Jiao, Baihai ^{[2
]}

Qu, Lili ^{[3
]}

Yang, Duomeng ^{[3
]}

Liu, Ruijuan ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Pharm, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[2] Univ Connecticut, Sch Med, Dept Med, Div Nephrol,Hlth Ctr, Farmington, CT USA

[3] Univ Connecticut, Sch Med, Dept Immunol, Hlth Ctr, Farmington, CT 06269 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

COVID-19; treatments; antiviral agents; neutralizing antibody therapy; Janus kinase inhibitors; JAK-STAT PATHWAY; OPEN-LABEL; CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; RUXOLITINIB; STANDARD; MULTICENTER; FAVIPIRAVIR; TOFACITINIB; COMBINATION;

D O I：

10.3389/fimmu.2023.1125246

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest worldwide public health threat of this century. Recent studies have unraveled numerous mysteries of SARS-CoV-2 pathogenesis and thus largely improved the studies of COVID-19 vaccines and therapeutic strategies. However, important questions remain regarding its therapy. In this review, the recent research advances on COVID-19 mechanism are quickly summarized. We mainly discuss current therapy strategies for COVID-19, with an emphasis on antiviral agents, neutralizing antibody therapies, Janus kinase inhibitors, and steroids. When necessary, specific mechanisms and the history of therapy are present, and representative strategies are described in detail. Finally, we discuss key outstanding questions regarding future directions of the development of COVID-19 treatment.

引用

页数：13

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