The development of COVID-19 treatment

被引：153

作者：

Yuan, Yongliang ^{[1
]}

Jiao, Baihai ^{[2
]}

Qu, Lili ^{[3
]}

Yang, Duomeng ^{[3
]}

Liu, Ruijuan ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Pharm, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[2] Univ Connecticut, Sch Med, Dept Med, Div Nephrol,Hlth Ctr, Farmington, CT USA

[3] Univ Connecticut, Sch Med, Dept Immunol, Hlth Ctr, Farmington, CT 06269 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

COVID-19; treatments; antiviral agents; neutralizing antibody therapy; Janus kinase inhibitors; JAK-STAT PATHWAY; OPEN-LABEL; CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; RUXOLITINIB; STANDARD; MULTICENTER; FAVIPIRAVIR; TOFACITINIB; COMBINATION;

D O I：

10.3389/fimmu.2023.1125246

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest worldwide public health threat of this century. Recent studies have unraveled numerous mysteries of SARS-CoV-2 pathogenesis and thus largely improved the studies of COVID-19 vaccines and therapeutic strategies. However, important questions remain regarding its therapy. In this review, the recent research advances on COVID-19 mechanism are quickly summarized. We mainly discuss current therapy strategies for COVID-19, with an emphasis on antiviral agents, neutralizing antibody therapies, Janus kinase inhibitors, and steroids. When necessary, specific mechanisms and the history of therapy are present, and representative strategies are described in detail. Finally, we discuss key outstanding questions regarding future directions of the development of COVID-19 treatment.

引用

页数：13

共 184 条

[1] Fourth COVID-19 Vaccine Dose Increases Low Antibodies [J].

Abbasi, Jennifer .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (06) :517-517

[2] Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia [J].

Abizanda, Pedro ;

Calbo Mayo, Juan Maria ;

Mas Romero, Marta ;

Cortes Zamora, Elisa Belen ;

Tabernero Sahuquillo, Maria Teresa ;

Romero Rizos, Luis ;

Sanchez-Jurado, Pedro Manuel ;

Sanchez-Nievas, Gines ;

Campayo Escolano, Carlos ;

Ochoa Serrano, Alba ;

Sanchez-Flor Alfaro, Victoria ;

Lopez Bru, Rita ;

Gomez Ballesteros, Cristina ;

Caldevilla Bernardo, David ;

Callejas Gonzalez, Francisco Javier ;

Andres-Pretel, Fernando ;

Lauschke, Volker Martin ;

Stebbing, Justin .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2021, 69 (10) :2752-2758

[3] A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 [J].

Lundgren J.D. ;

Grund B. ;

Barkauskas C.E. ;

Holland T.L. ;

Gottlieb R.L. ;

Sandkovsky U. ;

Brown S.M. ;

Knowlton K.U. ;

Self W.H. ;

Files D.C. ;

Jain M.K. ;

Benfield T. ;

Bowdish M.E. ;

Leshnower B.G. ;

Baker J.V. ;

Jensen J.-U. ;

Gardner E.M. ;

Ginde A.A. ;

Harris E.S. ;

Johansen I.S. ;

Markowitz N. ;

Matthay M.A. ;

Østergaard L. ;

Chang C.C. ;

Davey V.J. ;

Goodman A. ;

Higgs E.S. ;

Murray D.D. ;

Murray T.A. ;

Paredes R. ;

Parmar M.K.B. ;

Phillips A.N. ;

Reilly C. ;

Sharma S. ;

Dewar R.L. ;

Teitelbaum M. ;

Wentworth D. ;

Cao H. ;

Klekotka P. ;

Babiker A.G. ;

Gelijns A.C. ;

Kan V.L. ;

Polizzotto M.N. ;

Thompson B.T. ;

Lane H.C. ;

Neaton J.D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (10) :905-914

[4] Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial [J].

Ader, Florence ;

Bouscambert-Duchamp, Maude ;

Hites, Maya ;

Peiffer-Smadja, Nathan ;

Poissy, Julien ;

Belhadi, Drifa ;

Diallo, Alpha ;

Le, Minh-Patrick ;

Peytavin, Gilles ;

Staub, Therese ;

Greil, Richard ;

Guedj, Jeremie ;

Paiva, Jose-Artur ;

Costagliola, Dominique ;

Yazdanpanah, Yazdan ;

Burdet, Charles ;

Mentre, France .

LANCET INFECTIOUS DISEASES, 2022, 22 (02) :209-221

[5] Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial [J].

Agusti, Alvar ;

De Stefano, Gaston ;

Levi, Alberto ;

Munoz, Xavier ;

Romero-Mesones, Christian ;

Sibila, Oriol ;

Lopez-Giraldo, Alejandra ;

Moral, Vicente Plaza ;

Curto, Elena ;

Echazarreta, Andres L. ;

Marquez, Silvana E. ;

Pascual-Guardia, Sergi ;

Santos, Salud ;

Marin, Alicia ;

Valdes, Luis ;

Saldarini, Fernando ;

Salgado, Clara ;

Casanovas, Georgina ;

Varea, Sara ;

Rios, Jose ;

Faner, Rosa .

EUROPEAN RESPIRATORY JOURNAL, 2022, 59 (03)

[6] Enfuvirtide, an HIV-1 fusion inhibitor peptide, can act as a potent SARS-CoV-2 fusion inhibitor: an in silico drug repurposing study [J].

Ahmadi, Khadijeh ;

Farasat, Alireza ;

Rostamian, Mosayeb ;

Johari, Behrooz ;

Madanchi, Hamid .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (12) :5566-5576

[7] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[8] High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19 a randomised, placebo-controlled trial [J].

Alemany, Andrea ;

Millat-Martinez, Pere ;

Corbacho-Monne, Marc ;

Malchair, Pierre ;

Ouchi, Dan ;

Ruiz-Comellas, Anna ;

Ramirez-Morros, Anna ;

Rodriguez Codina, Joana ;

Amado Simon, Rosa ;

Videla, Sebastian ;

Costes, Gelia ;

Capdevila-Jauregui, Mar ;

Torrano-Soler, Pamela ;

San Jose, Alba ;

Papell, Gloria Bonet ;

Puig, Jordi ;

Otero, Aurema ;

Ruibal Suarez, Jose Carlos ;

Zarauza Pellejero, Alvaro ;

Llopis Roca, Ferran ;

Rodriguez Cortez, Orlando ;

Garcia Garcia, Vanesa ;

Vidal-Alaball, Josep ;

Millan, Anna ;

Contreras, Enric ;

Grifols, Joan-Ramon ;

Ancochea, Agueda ;

Galvan-Femenia, Ivan ;

Piccolo Ferreira, Francini ;

Bonet, Mireia ;

Cantoni, Jordi ;

Prat, Nuria ;

Ara, Jordi ;

Forcada Arcarons, Anna ;

Farre, Magi ;

Pradenas, Edwards ;

Blanco, Julia ;

Angel Rodriguez-Arias, Miquel ;

Fernandez Rivas, Gema ;

Marks, Michael ;

Bassat, Quique ;

Blanco, Ignacio ;

Baro, Barbara ;

Clotet, Bonaventura ;

Mitja, Oriol .

LANCET RESPIRATORY MEDICINE, 2022, 10 (03) :278-288

[9] COVID-19 vaccination: The road ahead [J].

Altmann, Daniel M. ;

Boyton, Rosemary J. .

SCIENCE, 2022, 375 (6585) :1127-1132

[10] Real-world analysis of main clinical outcomes in patients with polycythemia vera treated with ruxolitinib or best available therapy after developing resistance/intolerance to hydroxyurea [J].

Alvarez-Larran, Alberto ;

Garrote, Marta ;

Ferrer-Marin, Francisca ;

Perez-Encinas, Manuel ;

Mata-Vazquez, M. Isabel ;

Bellosillo, Beatriz ;

Arellano-Rodrigo, Eduardo ;

Gomez, Montse ;

Garcia, Regina ;

Garcia-Gutierrez, Valentin ;

Gasior, Mercedes ;

Cuevas, Beatriz ;

Angona, Anna ;

Gomez-Casares, Maria Teresa ;

Martinez, Clara M. ;

Magro, Elena ;

Ayala, Rosa ;

del Orbe-Barreto, Rafael ;

Perez-Lopez, Raul ;

Fox, Maria Laura ;

Raya, Jose-Maria ;

Guerrero, Lucia ;

Garcia-Hernandez, Carmen ;

Caballero, Gonzalo ;

Murillo, Ilda ;

Xicoy, Blanca ;

Ramirez, M. Jose ;

Carreno-Tarragona, Gonzalo ;

Hernandez-Boluda, Juan Carlos ;

Pereira, Arturo .

CANCER, 2022, 128 (13) :2441-2448

← 1 2 3 4 5 6 7 8 9 10 →