DIPEA-Assisted Efficient One-Pot Three-Component Synthesis of Novel β-Carboline Tethered Pyran Derivatives

被引：1
作者：
Banyal, Naveen [1 ,2 ]
Malakar, Chandi C. [3 ]
Kumar, Rakesh [1 ]
Singh, Virender [2 ]
机构：
[1] Dr BR Ambedkar Natl Inst Technol, Dept Chem, Jalandhar 144027, Punjab, India
[2] Cent Univ Punjab, Dept Chem, Bathinda 151004, Punjab, India
[3] Natl Inst Technol, Dept Chem, Imphal 795004, India
来源：
CHEMISTRYSELECT | 2024年 / 9卷 / 03期
关键词：
beta-Carboline; Kumujian C; Metal-free; Multicomponenty; Pyran Synthesis; METAL-FREE APPROACH; BIOLOGICAL EVALUATION; FACILE SYNTHESIS; IN-VITRO; ANALOGS; INHIBITOR; DISCOVERY; ALKALOIDS; BROVINCAMINE; DIVERSITY;
D O I：
10.1002/slct.202304751
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A potential DIPEA-assisted approach has been unfolded for the synthesis of novel beta-carboline tethered-4H-pyran derivatives via one-pot condensation of 1-formyl-9H-beta-carbolines, beta-keto esters and malononitrile in ethanol at ambient temperature. A library of 28 new beta-carboline tethered 4H-pyran derivatives has been developed. The significant features of the present strategy include high efficiency, excellent yield, inexpensive catalyst, mild reaction conditions, multicomponent character of reaction and simple purification procedure.
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页数：10
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