Association of Rs7217186 Polymorphism of Arachidonic Acid 15-Lipoxygenase (ALOX15) Gene with Susceptibility to Allergic Rhinitis

被引：0

作者：

Eivazi, Atefeh ^{[1
]}

Akbari, Bahman ^{[2
]}

Falahi, Sara ^{[1
]}

Karaji, Ali Gorgin ^{[3
]}

Rezaiemanesh, Alireza ^{[3
]}

Mortazavi, Seyed Hamid Reza ^{[4
]}

Daneshfar, Niloofar ^{[1
]}

Salari, Farhad ^{[3
]}

机构：

[1] Kermanshah Univ Med Sci, Student Res Comm, Sch Med, Kermanshah, Iran

[2] Kermanshah Univ Med Sci, Sch Med, Dept Biotechnol, Kermanshah, Iran

[3] Kermanshah Univ Med Sci, Sch Med, Dept Immunol, Kermanshah, Iran

[4] Kermanshah Univ Med Sci, Sch Med, Dept Pediat, Kermanshah, Iran

来源：

REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2023年 / 12卷 / 02期

关键词：

Allergic rhinitis; Arachidonate; 15-lipoxygenase; Immunoresolvents; Single-nucleotide; polymorphism; Specialized proresolving lipid mediators (SPMs); CORONARY-ARTERY-DISEASE; INFLAMMATION; RESOLUTION; MEDIATORS; RISK;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Allergic rhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins.Methods: In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX (ALOX15) gene, using SNPinfo and Regulome DB tools.Results: The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (P> 0.05).Conclusions: The present results indicated that rs7217186 polymorphism of ALOX15 gene might be a potential biomarker for susceptibility to AR.

引用

页码：269 / 276

页数：8

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