Long-term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence

被引：0

作者：

Fujisawa, Takeshi ^{[1
,2
,3
]}

Motegi, Atsushi ^{[1
,3
]}

Hirata, Hidenari ^{[1
,3
,6
]}

Zenda, Sadamoto ^{[1
,3
]}

Hojo, Hidehiro ^{[1
,3
]}

Nakamura, Masaki ^{[1
,3
]}

Oyoshi, Hidekazu ^{[1
]}

Tomizawa, Kento ^{[1
]}

Zhou, Yuzheng ^{[1
]}

Fukushi, Keiko ^{[1
]}

Kageyama, Shun-Ichiro ^{[1
,3
]}

Enokida, Tomohiro ^{[4
]}

Okano, Susumu ^{[4
]}

Tahara, Makoto ^{[4
]}

Shinozaki, Takeshi ^{[5
]}

Hayashi, Ryuichi ^{[5
]}

Matsuura, Kazuto ^{[5
]}

Akimoto, Tetsuo ^{[1
,3
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Radiat Oncol, Kashiwa, Japan

[2] Juntendo Univ, Grad Sch Med, Course Adv Clin Res Canc, Tokyo, Japan

[3] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Radiat Oncol & Particle Therapy, Kashiwa, Japan

[4] Natl Canc Ctr Hosp East, Dept Head & Neck Med Oncol, Kashiwa, Japan

[5] Natl Canc Ctr Hosp East, Dept Head & Neck Surg, Kashiwa, Japan

[6] Natl Canc Ctr Hosp East, Dept Radiat Oncol, 6-5-1 Kashiwanoha, Kashiwa 2778577, Japan

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2024年 / 46卷 / 03期

关键词：

cervical lymph node recurrence; long-term outcomes; oral cavity cancer; postoperative radiotherapy; salvage neck dissection; SQUAMOUS-CELL CARCINOMA; TONGUE CANCER; SURVIVAL; RISK;

D O I：

10.1002/hed.27609

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Backgrounds: We aimed to clarify the outcomes of postoperative radiotherapy (PORT) after salvage neck dissection for cervical lymph node (LN) recurrence in oral cavity cancer.Methods: We retrospectively evaluated overall survival (OS), recurrence-free survival (RFS), recurrence patterns, and adverse events of 51 patients with high-risk features receiving PORT after salvage neck dissection between 2009 and 2019.Results: After a median follow-up of 7.4 years from PORT initiation, the 7-year OS and RFS rates were 66.3% (95% CI: 54.0-81.3) and 54.6% (95% CI: 42.1-70.9), respectively. Age <70 years and isolated LN recurrence were significantly associated with longer OS and RFS. Among the 22 patients who experienced recurrence, 14 experienced recurrence within the radiation field. PORT-related grade 3 acute mucositis (35%) and late adverse events (osteoradionecrosis [4%] and laryngeal stenosis [2%]) were observed.Conclusions: PORT after salvage neck dissection for cervical LN recurrence achieved good survival with acceptable toxicity.

引用

页码：541 / 551

页数：11

共 50 条

[21] Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience
den Toom, Inne J.
Boeve, Koos
Lobeek, Daphne
Bloemena, Elisabeth
Donswijk, Maarten L.
de Keizer, Bart
Klop, W. Martin C.
Leemans, C. Rene
Willems, Stefan M.
Takes, Robert P.
Witjes, Max J. H.
de Bree, Remco
CANCERS, 2020, 12 (07) : 1 - 13
[22] Pattern of failure and long-term morbidity in patients undergoing postoperative radiotherapy for cervical cancer
Jain, P.
Hunter, R. D.
Livsey, J. E.
Coyle, C.
Kitchener, H. C.
Swindell, R.
Davidson, S. E.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2006, 16 (05) : 1839 - 1845
[23] Delayed lymph node metastases after elective neck dissection in patients with oral and oropharyngeal cancer and pN0 neck
Hoch, Stephan
Fasunla, James
Eivazi, Behfar
Werner, Jochen Alfred
Teymoortash, Afshin
AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2012, 33 (05) : 505 - 509
[24] Proactive Swallowing Rehabilitation in Patients with Recurrent Oral Cancer Receiving Salvage Treatment: Long-Term Swallowing-Related Outcomes
Li, Tzu-Hsiang
Tseng, Wen-Hsuan
Chiu, Hsiang-Ling
Yang, Tsung-Lin
Wang, Cheng-Ping
Chen, Tseng-Cheng
Chen, Chun-Nan
Lin, Mei-Chun
Ko, Jenq-Yuh
Lou, Pei-Jen
DYSPHAGIA, 2023, 38 (03) : 954 - 964
[25] Proactive Swallowing Rehabilitation in Patients with Recurrent Oral Cancer Receiving Salvage Treatment: Long-Term Swallowing-Related Outcomes
Tzu-Hsiang Li
Wen-Hsuan Tseng
Hsiang-Ling Chiu
Tsung-Lin Yang
Cheng-Ping Wang
Tseng-Cheng Chen
Chun-Nan Chen
Mei-Chun Lin
Jenq-Yuh Ko
Pei-Jen Lou
Dysphagia, 2023, 38 : 954 - 964
[26] Low risk of contralateral lymph node recurrence in lateralized head and neck carcinoma after postoperative ipsilateral radiotherapy
Wirtz, Mirja M.
Temming, Susanne
Kocher, Martin
Kunze, Sabine
Semrau, Robert
STRAHLENTHERAPIE UND ONKOLOGIE, 2020, 196 (05) : 474 - 484
[27] Long-term clinical outcomes after high and low ligations with lymph node dissection around the root of the inferior mesenteric artery in patients with rectal cancer
Lee, Min Wan
Park, Sung Sil
You, Kiho
Lee, Dong Eun
Lee, Dong Woon
Park, Sung Chan
Han, Kyung Su
Sohn, Dae Kyung
Hong, Chang Won
Kim, Bun
Kim, Byung Chang
Chang, Hee Jin
Kim, Dae Yong
Oh, Jae Hwan
ANNALS OF COLOPROCTOLOGY, 2024, 40 (01) : 62 - 73
[28] Risk factors for lymph node metastasis and long-term outcomes of patients with early gastric cancer after non-curative endoscopic submucosal dissection
Kawata, Noboru
Kakushima, Naomi
Takizawa, Kohei
Tanaka, Masaki
Makuuchi, Rie
Tokunaga, Masanori
Tanizawa, Yutaka
Bando, Etsuro
Kawamura, Taiichi
Sugino, Takashi
Kusafuka, Kimihide
Shimoda, Tadakazu
Nakajima, Takashi
Terashima, Masanori
Ono, Hiroyuki
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2017, 31 (04): : 1607 - 1616
[29] Risk factors for lymph node metastasis and long-term outcomes of patients with early gastric cancer after non-curative endoscopic submucosal dissection
Noboru Kawata
Naomi Kakushima
Kohei Takizawa
Masaki Tanaka
Rie Makuuchi
Masanori Tokunaga
Yutaka Tanizawa
Etsuro Bando
Taiichi Kawamura
Takashi Sugino
Kimihide Kusafuka
Tadakazu Shimoda
Takashi Nakajima
Masanori Terashima
Hiroyuki Ono
Surgical Endoscopy, 2017, 31 : 1607 - 1616
[30] Study of therapeutic results, lymph node ratio, short-term and long-term complications of lateral lymph node dissection in rectal cancer patients
Mahmoodzadeh, Habibollah
Omranipour, Ramesh
Borjian, Anahita
Borjian, Mohammad Amin
TURKISH JOURNAL OF SURGERY, 2020, 36 (02) : 224 - 228

← 1 2 3 4 5 →