Long-term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence

被引：0

作者：

Fujisawa, Takeshi ^{[1
,2
,3
]}

Motegi, Atsushi ^{[1
,3
]}

Hirata, Hidenari ^{[1
,3
,6
]}

Zenda, Sadamoto ^{[1
,3
]}

Hojo, Hidehiro ^{[1
,3
]}

Nakamura, Masaki ^{[1
,3
]}

Oyoshi, Hidekazu ^{[1
]}

Tomizawa, Kento ^{[1
]}

Zhou, Yuzheng ^{[1
]}

Fukushi, Keiko ^{[1
]}

Kageyama, Shun-Ichiro ^{[1
,3
]}

Enokida, Tomohiro ^{[4
]}

Okano, Susumu ^{[4
]}

Tahara, Makoto ^{[4
]}

Shinozaki, Takeshi ^{[5
]}

Hayashi, Ryuichi ^{[5
]}

Matsuura, Kazuto ^{[5
]}

Akimoto, Tetsuo ^{[1
,3
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Radiat Oncol, Kashiwa, Japan

[2] Juntendo Univ, Grad Sch Med, Course Adv Clin Res Canc, Tokyo, Japan

[3] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Div Radiat Oncol & Particle Therapy, Kashiwa, Japan

[4] Natl Canc Ctr Hosp East, Dept Head & Neck Med Oncol, Kashiwa, Japan

[5] Natl Canc Ctr Hosp East, Dept Head & Neck Surg, Kashiwa, Japan

[6] Natl Canc Ctr Hosp East, Dept Radiat Oncol, 6-5-1 Kashiwanoha, Kashiwa 2778577, Japan

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2024年 / 46卷 / 03期

关键词：

cervical lymph node recurrence; long-term outcomes; oral cavity cancer; postoperative radiotherapy; salvage neck dissection; SQUAMOUS-CELL CARCINOMA; TONGUE CANCER; SURVIVAL; RISK;

D O I：

10.1002/hed.27609

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Backgrounds: We aimed to clarify the outcomes of postoperative radiotherapy (PORT) after salvage neck dissection for cervical lymph node (LN) recurrence in oral cavity cancer.Methods: We retrospectively evaluated overall survival (OS), recurrence-free survival (RFS), recurrence patterns, and adverse events of 51 patients with high-risk features receiving PORT after salvage neck dissection between 2009 and 2019.Results: After a median follow-up of 7.4 years from PORT initiation, the 7-year OS and RFS rates were 66.3% (95% CI: 54.0-81.3) and 54.6% (95% CI: 42.1-70.9), respectively. Age <70 years and isolated LN recurrence were significantly associated with longer OS and RFS. Among the 22 patients who experienced recurrence, 14 experienced recurrence within the radiation field. PORT-related grade 3 acute mucositis (35%) and late adverse events (osteoradionecrosis [4%] and laryngeal stenosis [2%]) were observed.Conclusions: PORT after salvage neck dissection for cervical LN recurrence achieved good survival with acceptable toxicity.

引用

页码：541 / 551

页数：11

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