The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments

被引:18
作者
Benavides-Aguilar, Javier A. [1 ,2 ]
Torres-Copado, Andrea [2 ]
Isidoro-Sanchez, Jose [2 ]
Pathak, Surajit [3 ]
Duttaroy, Asim K. [4 ]
Banerjee, Antara [3 ]
Paul, Sujay [2 ]
机构
[1] Tech Univ Denmark, DK-2800 Lyngby, Denmark
[2] Tecnol Monterrey, Sch Engn & Sci, NatProLab Plant Innovat Lab, Queretaro 76130, Mexico
[3] Chettinad Acad Res & Educ CARE, Chettinad Hosp & Res Inst CHRI, Fac Allied Hlth Sci, Dept Med Biotechnol, Chennai 603103, India
[4] Univ Oslo, Inst Basic Med Sci, Fac Med, Dept Nutr, POB 1046, N-0316 Oslo, Norway
关键词
miRNA; obesity; adipogenesis; lipogenesis; adipose tissue; AGGRAVATES OBESITY; EXOSOMAL MIRNAS; ADIPOSE-TISSUE; ADIPOGENESIS;
D O I
10.3390/genes14112070
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Obesity is a condition that is characterized by the presence of excessive adipose tissue in the body. Obesity has become one of the main health concerns worldwide since it can lead to other chronic ailments, such as type 2 diabetes or fatty liver disease, and it could be an aggravating factor in infections. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression and can play an important role in controlling crucial biological processes involved in the onset of obesity, such as lipogenesis, adipogenesis, lipid metabolism, or the regulation of cytokines and chemokines. Moreover, chemical compounds present in food or food packaging can alter miRNA expression and regulate the aforementioned biological mechanisms related to diabetes onset and progression. Furthermore, therapies, such as bariatric surgery and aerobic exercise training, can also influence the expression profile of miRNAs in obesity. Therefore, the present review provides insight into the current research on the role of miRNAs in obesity and obesity-derived ailments, intending to develop novel therapies to effectively manage these disorders.
引用
收藏
页数:14
相关论文
共 74 条
[1]   MicroRNAs in obesity-associated disorders [J].
Abente, Eugenio J. ;
Subramanian, Murugan ;
Ramachandran, Vimal ;
Najafi-Shoushtari, S. Hani .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2016, 589 :108-119
[2]   Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3 [J].
Abu-Farha, Mohamed ;
Cherian, Preethi ;
Al-Khairi, Irina ;
Nizam, Rasheeba ;
Alkandari, Abdullah ;
Arefanian, Hossein ;
Tuomilehto, Jaakko ;
Al-Mulla, Fahd ;
Abubaker, Jehad .
SCIENTIFIC REPORTS, 2019, 9 (1)
[3]   Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery [J].
Atkin, Stephen L. ;
Ramachandran, Vimal ;
Yousri, Noha A. ;
Benurwar, Manasi ;
Simper, Steven C. ;
McKinlay, Rodrick ;
Adams, Ted D. ;
Najafi-Shoushtari, S. Hani ;
Hunt, Steven C. .
FRONTIERS IN ENDOCRINOLOGY, 2019, 9
[4]   Updates on Monogenic Obesity in a Multifactorial Disease [J].
Baxter, Jared ;
Armijo, Priscila Rodrigues ;
Flores, Laura ;
Krause, Crystal ;
Samreen, Sarah ;
Tanner, Tiffany .
OBESITY SURGERY, 2019, 29 (12) :4077-4083
[5]   Targeting miRNAs and Other Non-Coding RNAs as a Therapeutic Approach: An Update [J].
Bayraktar, Emine ;
Bayraktar, Recep ;
Oztatlici, Hulya ;
Lopez-Berestein, Gabriel ;
Amero, Paola ;
Rodriguez-Aguayo, Cristian .
NON-CODING RNA, 2023, 9 (02)
[6]   The regulatory role of microRNAs in common eye diseases: A brief review [J].
Benavides-Aguilar, Javier A. ;
Morales-Rodriguez, Jonathan I. ;
Ambriz-Gonzalez, Hector ;
Ruiz-Manriquez, Luis M. ;
Banerjee, Antara ;
Pathak, Surajit ;
Duttaroy, Asim K. ;
Paul, Sujay .
FRONTIERS IN GENETICS, 2023, 14
[7]   MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications [J].
Bravo-Vazquez, Luis Alberto ;
Frias-Reid, Natalia ;
Ramos-Delgado, Ana Gabriela ;
Osorio-Perez, Sofia Madeline ;
Zlotnik-Chavez, Hania Ruth ;
Pathak, Surajit ;
Banerjee, Antara ;
Bandyopadhyay, Anindya ;
Duttaroy, Asim K. ;
Paul, Sujay .
TRANSLATIONAL ONCOLOGY, 2023, 27
[8]   Humans against Obesity: Who Will Win? [J].
Caballero, Benjamin .
ADVANCES IN NUTRITION, 2019, 10 :S4-S9
[9]   Evaluation of Exosomal Coding and Non-Coding RNA Signature in Obese Adolescents [J].
Cabiati, Manuela ;
Randazzo, Emioli ;
Guiducci, Letizia ;
Falleni, Alessandra ;
Cecchettini, Antonella ;
Casieri, Valentina ;
Federico, Giovanni ;
Del Ry, Silvia .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
[10]   miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity [J].
Chang, Richard C. ;
Joloya, Erika M. ;
Li, Zhuorui ;
Shoucri, Bassem M. ;
Shioda, Toshi ;
Blumberg, Bruce .
ENDOCRINOLOGY, 2023, 164 (05)