n-6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies

被引：6

作者：

Garg, Parveen K. ^{[1
]}

Guan, Weihua ^{[2
]}

Nomura, Sarah ^{[3
]}

Weir, Natalie L. ^{[3
]}

Tintle, Nathan ^{[4
]}

Virtanen, Jyrki K. ^{[5
]}

Hirakawa, Yoichiro ^{[6
]}

Qian, Frank ^{[7
,8
]}

Sun, Qi ^{[7
]}

Rimm, Eric ^{[7
]}

Lemaitre, Rozenn N. ^{[9
]}

Jensen, Paul N. ^{[9
]}

Heckbert, Susan R. ^{[10
]}

Imamura, Fumiaki ^{[11
]}

Steur, Marinka ^{[12
]}

Leander, Karin ^{[13
]}

Laguzzi, Federica ^{[13
]}

Voortman, Trudy ^{[12
]}

Ninomiya, Toshiharu ^{[14
,15
]}

Mozaffarian, Dariush ^{[16
,17
]}

Harris, William S. ^{[18
]}

Siscovick, David S. ^{[19
]}

Tsai, Michael Y. ^{[3
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Div Cardiol, Los Angeles, CA 90007 USA

[2] Univ Minnesota, Div Biostat, Minneapolis, MN USA

[3] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[4] Univ Illinois, Coll Nursing, Dept Populat Hlth Sci, Chicago, IL USA

[5] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

[6] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[8] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA

[9] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[10] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[11] Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England

[12] Univ Med Ctr, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[13] Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden

[14] Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Japan

[15] Kyushu Univ, Ctr Cohort Studies, Grad Sch Med Sci, Fukuoka, Japan

[16] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA

[17] Tufts Med Ctr, Div Cardiol, Boston, MA 02111 USA

[18] Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA

[19] New York Acad Med, New York, NY USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2023年 / 118卷 / 05期

关键词：

atrial arrhythmia; cardiovascular disease; primary prevention; polyunsaturated fatty acids; prospective cohorts; Fatty Acids and Outcomes Research Consortium; LINOLEIC-ACID; RISK-FACTORS; INFLAMMATION; ERYTHROCYTE; PROJECTIONS; OMEGA-3; PLASMA;

D O I：

10.1016/j.ajcnut.2023.09.008

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: The presence of atrial fibrillation (AF) is associated with an over 2-fold increased risk of stroke, heart failure, and cardiovascular mortality. Long chain n-6 PUFAs have been suggested to have a variety of beneficial biologic effects that may reduce AF development; however, prior studies evaluating this relationship are limited.Objectives: We prospectively evaluated the association between circulating levels of linoleic acid (LA) and arachidonic acid (AA) with incident AF.Methods: We used participant-level data from a global consortium of 11 prospective cohort studies with measurements of LA and AA in adults (aged >= 18 y). Participating studies conducted de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcomes, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis.Results: Among 41,335 participants, 6173 incident cases of AF were ascertained, with median follow-up time of 14 y. In multivariable analysis, per interquintile range (difference between the 10th and 90th percentiles for each fatty acid), circulating n-6 levels were not associated with incident AF. For LA, the hazard ratio per interquintile range was 0.96 (95% confidence interval [CI]: 0.89, 1.04), and for AA, 1.02 (95% CI: 0.94, 1.10), with little evidence of heterogeneity between cohorts. Associations were similarly nonsignificant across subgroups of age, race, and biomarker fraction.Conclusions: Biomarkers of n-6 fatty acids including LA and AA are not associated with incident AF. These findings suggest that overall effects of n-6 PUFAs on influencing AF development are neutral.

引用

页码：921 / 929

页数：9

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