The Role of Stem Cell on Wound Healing After Revascularization-Healing Following Revascularization-Unlocking Skin Potential

被引:2
|
作者
Cheng, Biao [1 ]
Fu, Xiaobing [2 ,3 ,4 ,5 ]
机构
[1] Gen Hosp Southern Theater Command PLA, Dept Burns & Plast Surg, Guangzhou, Peoples R China
[2] Peoples Liberat Army Gen Hosp, Res Ctr Tissue Repair & Regenerat, Med Innovat Res Dept, 2019RU051, Beijing 100048, Peoples R China
[3] PLA Med Coll, 2019RU051, Beijing 100048, Peoples R China
[4] Beijing Key Res Lab Skin Injury Repair & Regenerat, 2019RU051, Beijing 100048, Peoples R China
[5] Chinese Acad Med Sci, Res Unit Trauma Care Tissue Repair & Regenerat, 2019RU051, Beijing 100048, Peoples R China
关键词
revascularization; wound management; wound healing; redox; stem cells; mitochondria; DYNAMIC MICROENVIRONMENT; METABOLIC-REGULATION; REDOX HOMEOSTASIS; OXIDATIVE STRESS; MITOCHONDRIAL; OXYGEN; FATE; MECHANISMS; REGENERATION; CONTRIBUTES;
D O I
10.1177/15347346231210709
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Wound healing is a complex and dynamic process involving a series of cellular and molecular events. Revascularization, the restoration of blood flow to ischemic or damaged tissue, is a key step in wound healing. Adequate vascularization has been recognized as a necessary factor for successful tissue regeneration. In the later stage of revascularization and tissue remodeling in wound healing, stem cells regulate other repair cells and matrix formation by influencing the maturation of blood vessels. The reductive oxidation (REDOX) state may be a key mechanism through stem/progenitor cells to influence endothelial cells to mature blood vessels and improve the quality of healing. Mitochondria may play an important role in this process.
引用
收藏
页码:63 / 69
页数:7
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