Antioxidant and anti-inflammatory effects of allicin in the kidney of an experimental model of metabolic syndrome

被引:5
|
作者
Buendia, Abraham Said Arellano [1 ,2 ]
Rojas, Juan Gabriel Juarez [3 ]
Garcia-Arroyo, Fernando [2 ]
Trejo, Omar Emiliano Aparicio [2 ]
Sanchez-Munoz, Fausto [4 ]
Arguello-Garcia, Raul [5 ]
Sanchez-Lozada, Laura Gabriela [2 ]
Bojalil, Rafael [6 ]
Osorio-Alonso, Horacio [2 ]
机构
[1] Univ Autonoma Metropolitana, Ciencias Biol & Salud, Mexico City, Xochimilco, Mexico
[2] Inst Nacl Cardiol Ignacio Chavez, Fisiopatol Cardiorenal, Mexico City, Tlalpan, Mexico
[3] Inst Nacl Cardiol Ignacio Chavez, Endocrinol, Mexico City, Tlalpan, Mexico
[4] Inst Nacl Cardiol Ignacio Chavez, Inmunol, Mexico City, Tlalpan, Mexico
[5] Ctr Invest & Estudios Avanzados IPN, Genet & Biol Mol, Dept Genet & Biol Mo, Mexico City, Gustavo A Mader, Mexico
[6] Univ Autonoma Metropolitana, Atenc Salud, Mexico City, Xochimilco, Mexico
来源
PEERJ | 2023年 / 11卷
关键词
Metabolic syndrome; Allicin; Chronic kidney disease; Inflammation; Oxidative stress; Hypertension; MITOCHONDRIAL BIOENERGETICS; IMPAIRMENT; OXIDATION; FIBROSIS;
D O I
10.7717/peerj.16132
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Recent studies have suggested that metabolic syndrome (MS) encompasses a group of risk factors for developing chronic kidney disease (CKD). This work aimed to evaluate the antioxidant and anti-inflammatory effects of allicin in the kidney from an experimental model of MS.Methods: Male Wistar rats (220-250 g) were used, and three experimental groups (n = 6) were formed: control (C), metabolic syndrome (MS), and MS treated with allicin (16 mg/Kg/day, gastric gavage) (MS+A). MS was considered when an increase of 20% in at least three parameters (body weight, systolic blood pressure (SBP), fasting blood glucose (FBG), or dyslipidemia) was observed compared to the C group. After the MS diagnosis, allicin was administered for 30 days.Results: Before the treatment with allicin, the MS group showed more significant body weight gain, increased SBP, and FBG, glucose intolerance, and dyslipidemia. In addition, increased markers of kidney damage in urine and blood. Moreover, the MS increased oxidative stress and inflammation in the kidney compared to group C. The allicin treatment prevented further weight gain, reduced SBP, FBG, glucose intolerance, and dyslipidemia. Also, markers of kidney damage in urine and blood were decreased. Further, the oxidative stress and inflammation were decreased in the renal cortex of the MS+A compared to the MS group.Conclusion: Allicin exerts its beneficial effects on the metabolic syndrome by considerably reducing systemic and renal inflammation as well as the oxidative stress. These effects were mediated through the Nrf2 pathway. The results suggest allicin may be a therapeutic alternative for treating kidney injury induced by the metabolic syndrome risk factors.
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页数:23
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