The Case for Human Challenge Trials in COVID-19

被引：1

作者：

Drewett, George P. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Melbourne Law Sch, Parkville, Vic, Australia

[2] Northern Hosp, Epping, Vic, Australia

来源：

JOURNAL OF BIOETHICAL INQUIRY | 2024年 / 21卷 / 01期

关键词：

CHIT; Human challenge trial; Coronavirus; Sars-CoV-2; Vaccination; INFECTION; VACCINE; VOLUNTEERS; EFFICACY; PREVENTION; PAYMENT; ETHICS; FEVER; RISK;

D O I：

10.1007/s11673-023-10309-9

中图分类号：

B82 [伦理学（道德学）];

学科分类号：

摘要：

The COVID-19 pandemic has necessitated rapid research to aid in the understanding of the disease and the development of novel therapeutics. One option is to conduct controlled human infection trials (CHITs). In this article I examine the history of deliberate human infection and CHITs and their utilization prior to the COVID-19 pandemic, key ethical considerations of CHITs in the COVID-19 setting, an analysis of the World Health Organization's (WHO) Key criteria for the ethical acceptability of COVID-19 human challenge studies, and a review of the two COVID-19 CHITs that have already commenced, their compliance with the WHO criteria and other ethical considerations.

引用

页码：151 / 165

页数：15

共 75 条

[51]

National Health and Medical Research Council, 2022, PAYM PART RES INF RE

[52]

Office for National Statistics (ONS), 2021, COVID 19 SCH INF SUR

[53] Commentary on 'Payment in challenge studies: ethics, attitudes and a new payment for risk model' [J].

Payne, Ruth .

JOURNAL OF MEDICAL ETHICS, 2020, 46 (12) :829-830

[54] Extraordinary diseases require extraordinary solutions [J].

Plotkin, Stanley A. ;

Caplan, Arthur .

VACCINE, 2020, 38 (24) :3987-3988

[55] SARS-CoV-2 Human Challenge Studies - Establishing the Model during an Evolving Pandemic [J].

Rapeport, Garth ;

Smith, Emma ;

Gilbert, Anthony ;

Catchpole, Andrew ;

McShane, Helen ;

Chiu, Christopher .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (11) :961-964

[56] THE BEHAVIOR OF RECENT ISOLATES OF HUMAN RESPIRATORY CORONAVIRUS INVITRO AND IN VOLUNTEERS - EVIDENCE OF HETEROGENEITY AMONG 229E-RELATED STRAINS [J].

REED, SE .

JOURNAL OF MEDICAL VIROLOGY, 1984, 13 (02) :179-192

[57] Ethical guidelines for deliberately infecting volunteers with COVID-19 [J].

Richards, Adair D. .

JOURNAL OF MEDICAL ETHICS, 2020, 46 (08) :502-504

[58]

Riedel Stefan, 2005, Proc (Bayl Univ Med Cent), V18, P21

[59] Experimental infection of human volunteers [J].

Roestenberg, Meta ;

Hoogerwerf, Marie-Astrid ;

Ferreira, Daniela M. ;

Mordmueller, Benjamin ;

Yazdanbakhsh, Maria .

LANCET INFECTIOUS DISEASES, 2018, 18 (10) :E312-E322

[60] The Ethics of Human Challenge Trials Using Emerging Severe Acute Respiratory Syndrome 2 Variants [J].

Rohrig, Abie ;

Eyal, Nir .

JOURNAL OF INFECTIOUS DISEASES, 2022, 225 (06) :934-937

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