Molecular and Cellular Mechanisms of Action of Cannabidiol

被引：43

作者：

Naya, Nadia Martinez ^{[1
]}

Kelly, Jazmin ^{[1
]}

Corna, Giuliana ^{[2
,3
]}

Golino, Michele ^{[2
,4
]}

Abbate, Antonio ^{[1
,2
]}

Toldo, Stefano ^{[1
]}

机构：

[1] Univ Virginia, Robert M Berne Cardiovasc Res Ctr, Dept Med, Div Cardiovasc Med, Charlottesville, VA 22908 USA

[2] Virginia Commonwealth Univ, Pauley Heart Ctr, Dept Internal Med, Div Cardiol, Richmond, VA 22903 USA

[3] Hosp Italiano Buenos Aires, Intervent Cardiol Dept, RA-1199 Buenos Aires, Argentina

[4] Univ Insubria, Dept Med & Surg, I-2110 Varese, Italy

来源：

MOLECULES | 2023年 / 28卷 / 16期

关键词：

cannabidiol; CBD; inflammation; mechanisms; molecular target; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; IN-VITRO MODEL; NF-KAPPA-B; INDUCED APOPTOSIS; NITRIC-OXIDE; NEUTROPHIL POLARIZATION; CANNABINOID RECEPTORS; MULTIPLE-SCLEROSIS; OXIDATIVE STRESS; HIGH POTENCY;

D O I：

10.3390/molecules28165980

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cannabidiol (CBD) is the primary non-psychoactive chemical from Cannabis Sativa, a plant used for centuries for both recreational and medicinal purposes. CBD lacks the psychotropic effects of & UDelta;9-tetrahydrocannabinol (?9-THC) and has shown great therapeutic potential. CBD exerts a wide spectrum of effects at a molecular, cellular, and organ level, affecting inflammation, oxidative damage, cell survival, pain, vasodilation, and excitability, among others, modifying many physiological and pathophysiological processes. There is evidence that CBD may be effective in treating several human disorders, like anxiety, chronic pain, psychiatric pathologies, cardiovascular diseases, and even cancer. Multiple cellular and pre-clinical studies using animal models of disease and several human trials have shown that CBD has an overall safe profile. In this review article, we summarize the pharmacokinetics data, the putative mechanisms of action of CBD, and the physiological effects reported in pre-clinical studies to give a comprehensive list of the findings and major effects attributed to this compound.

引用

页数：24

共 178 条

[41] Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications [J].