Targeted Protein Degradation: Principles, Strategies, and Applications

被引：2

作者：

He, Ting ^{[1
]}

Wen, Chenxi ^{[1
]}

Yang, Guodong ^{[2
]}

Yang, Xuekang ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Lab Canc Biol, Xian 710032, Peoples R China

来源：

ADVANCED BIOLOGY | 2023年 / 7卷 / 12期

基金：

中国国家自然科学基金;

关键词：

autophagy-lysosome pathway; clinical application; endosome-lysosome system; targeted protein degradation; ubiquitin-proteasome system; 20S PROTEASOME; MEDIATED DEGRADATION; INDUCE DEGRADATION; STRUCTURAL BASIS; SMALL MOLECULES; MOUSE MODELS; UBIQUITIN; INHIBITION; KNOCKDOWN; AUTOPHAGY;

D O I：

10.1002/adbi.202300083

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Protein degradation is a general process to maintain cell homeostasis. The intracellular protein quality control system mainly includes the ubiquitin-proteasome system and the lysosome pathway. Inspired by the physiological process, strategies to degrade specific proteins have developed, which emerge as potent and effective tools in biological research and drug discovery. This review focuses on recent advances in targeted protein degradation techniques, summarizing the principles, advantages, and challenges. Moreover, the potential applications and future direction in biological science and clinics are also discussed.

引用

页数：12

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