Effect of Cornus mas L. fruit extract on blood pressure, anthropometric and body composition indices in patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial

被引：12

作者：

Yarhosseini, Faezeh ^{[1
,2
]}

Sangouni, Abbas Ali ^{[1
,2
]}

Sangse, Zohreh Sadat ^{[1
,2
]}

Hosseinzadeh, Mahdieh ^{[1
,2
]}

Akhondi-Meybodi, Mohsen ^{[3
]}

Ranjbar, Alimohammad ^{[4
,5
]}

Fallahzadeh, Hossein ^{[6
]}

Mozaffari-Khosravi, Hassan ^{[1
,2
]}

机构：

[1] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran

[2] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Publ Hlth, Yazd, Iran

[3] Shahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Fac Med, Gastroenterol Dept, Yazd, Iran

[4] Shahid Sadoughi Univ Med Sci, Fac Pharm, Dept Pharmacognosy, Yazd, Iran

[5] Shahid Sadoughi Univ Med Sci, Fac Pharm, Herbal Med Ctr, Yazd, Iran

[6] Shahid Sadoughi Univ Med Sci, Res Ctr Prevent & Epidemiol Noncommunicable Dis, Sch Publ Hlth, Dept Biostat & Epidemiol, Yazd, Iran

来源：

CLINICAL NUTRITION ESPEN | 2023年 / 56卷

关键词：

Non-alcoholic fatty liver disease; Cornus masL; Blood pressure; Obesity; CORNELIAN CHERRY; OXIDATIVE STRESS; RISK-FACTORS; ANTHOCYANINS; RELIABILITY; MANAGEMENT; OBESITY; ACID; STEATOHEPATITIS; RECOMMENDATIONS;

D O I：

10.1016/j.clnesp.2023.04.018

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background & aims: Obesity is linked to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Patients with NAFLD are at increased risk for hypertension. Some investigations have hypothesized that Cornus mas L. fruit can improve obesity and hypertension. We investigated the effect of C. mas L. fruit extract on blood pressure, anthropometric and body composition indices in patients with NAFLD.Methods: This 12-week double-blind randomized controlled trial was conducted on fifty patients with NAFLD. Patients received 20 cc/d C. mas L. fruit extract or placebo. We measured diastolic blood pressure (DBP), systolic blood pressure (SBP), weight, waist circumference (WC), hip circumference (HC), waist-tohip ratio (WHR), body fat mass (BFM), body fat percent (BFP) and fat free mass (FFM) before and after intervention.Results: Treatment group compared to control group showed a significant reduction in DBP (-8.62 +/- 11.86 mmHg vs. 0.53 +/- 8.53 mmHg; Pcrude = 0.003; Padjucted = 0.03) and SBP (-8.63 +/- 14.37 mmHg vs. 0.0 +/- 12.67 mmHg; Pcrude = 0.02; Padjucted = 0.02). We found no difference between groups in weight, WC, HC, WHR, BFM, BFP and FFM (P > 0.05). After adjusting for confounding factors, a significant reduction was observed in treatment group compared to control group in BFM (-0.2 +/- 3.9 kg vs. 0.7 +/- 2.4 kg; P = 0.01) and BFP (-0.2 +/- 4.9% vs. 0.8 +/- 2.8%; P = 0.02).Conclusions: C. mas L. fruit extract statistically reduced blood pressure and body fat. However, it had no effect on other anthropometric and body composition indices. Studies with larger sample sizes and higher dosages of extract are needed. Trial registration: Registered on 30/9/2018 at Iranian Registry of Clinical Trials IRCT20180419039359N1 (https://www.irct.ir/trial/30707).(c) 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

引用

页码：18 / 24

页数：7

共 59 条

[1] Protective Effect of Cornus mas Fruits Extract on Serum Biomarkers in CCl4-Induced Hepatotoxicity in Male Rats [J].