Treatment alternatives for multidrug-resistant fungal pathogens

被引：4
作者：
Roe, Kevin
机构：
[1] San Jose, CA
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 06期
关键词：
proteins; monoclonal antibodies; synthetic monoclonal antibodies; immune cells; fungal pathogens; fungal; infections; BLOOD-STREAM INFECTIONS; T-CELLS; GAMMA; SURVEILLANCE; ACTIVATION; ANTIBODIES; RECEPTOR; BARRIER;
D O I：
10.1016/j.drudis.2023.103596
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several fungal pathogens are becoming resistant to conventional fungal infection treatments, and some fungal pathogens have become multidrug-resistant. Alternative treatments include fungal vaccines, conventional or synthetic monoclonal antibody (mAb) injections, or potentially conventional or synthetic mAbs produced in vivo by injections of appropriately packaged mRNA. Specifically synthesized proteins can mask distinctive pathogenic fungal surface proteins and target pathogenic fungal proteins to stop fungal infections. Treatments could also use combinations of one or more antifungal drugs combined with direct injections or injections of packaged mRNA with instructions for patient synthesis of either the conventional or synthetic mAbs. These alternative treatments offer potentially significant advantages compared with existing treatments for fungal pathogens.
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页数：8
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共 60 条
[1]   Antifungal Macrocycle Antibiotic Amphotericin B-Its Present and Future. Multidisciplinary Perspective for the Use in the Medical Practice [J].
Baghirova, A. A. ;
Kasumov, Kh M. .
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY, 2022, 16 (01) :1-12
[2]   Hidden Killers: Human Fungal Infections [J].
Brown, Gordon D. ;
Denning, David W. ;
Gow, Neil A. R. ;
Levitz, Stuart M. ;
Netea, Mihai G. ;
White, Theodore C. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (165)
[3]   Exciting Developments in the Immunology of Fungal Infections [J].
Brown, Gordon D. ;
Netea, Mihai G. .
CELL HOST & MICROBE, 2012, 11 (05) :422-424
[4]   CXCR5 identifies a subset of Vγ9Vδ2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production [J].
Caccamo, Nadia ;
Battistini, Luca ;
Bonneville, Marc ;
Poccia, Fabrizio ;
Fournie, Jean Jacques ;
Meraviglia, Serena ;
Borsellino, Giovanna ;
Kroczek, Richard A. ;
La Mendola, Carmela ;
Scotet, Emmanuel ;
Dieli, Francesco ;
Salerno, Alfredo .
JOURNAL OF IMMUNOLOGY, 2006, 177 (08) :5290-5295
[5]   Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice [J].
Cavazzoni, Cecilia B. ;
Hanson, Benjamin L. ;
Podesta, Manuel A. ;
Bechu, Elsa D. ;
Clement, Rachel L. ;
Zhang, Hengcheng ;
Daccache, Joe ;
Reyes-Robles, Tamara ;
Hett, Erik C. ;
Vora, Kalpit A. ;
Fadeyi, Olugbeminiyi O. ;
Oslund, Rob C. ;
Hazuda, Daria J. ;
Sage, Peter T. .
CELL REPORTS, 2022, 38 (08)
[6]   Lung-resident γδ T cells and their roles in lung diseases [J].
Cheng, Min ;
Hu, Shilian .
IMMUNOLOGY, 2017, 151 (04) :375-384
[7]   Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally [J].
Chowdhary, Anuradha ;
Sharma, Cheshta ;
Meis, Jacques F. .
PLOS PATHOGENS, 2017, 13 (05)
[8]   Pentraxins in the activation and regulation of innate immunity [J].
Daigo, Kenji ;
Inforzato, Antonio ;
Barajon, Isabella ;
Garlanda, Cecilia ;
Bottazzi, Barbara ;
Meri, Seppo ;
Mantovani, Alberto .
IMMUNOLOGICAL REVIEWS, 2016, 274 (01) :202-217
[9]   A new humanized antibody is effective against pathogenic fungi in vitro [J].
Di Mambro, Tomas ;
Vanzolini, Tania ;
Bruscolini, Pierpaolo ;
Perez-Gaviro, Sergio ;
Marra, Emanuele ;
Roscilli, Giuseppe ;
Bianchi, Marzia ;
Fraternale, Alessandra ;
Schiavano, Giuditta Fiorella ;
Canonico, Barbara ;
Magnani, Mauro .
SCIENTIFIC REPORTS, 2021, 11 (01)
[10]   Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection [J].
Espeseth, Amy S. ;
Cejas, Pedro J. ;
Citron, Michael P. ;
Wang, Dai ;
DiStefano, Daniel J. ;
Callahan, Cheryl ;
O'Donnell, Gregory ;
Galli, Jennifer D. ;
Swoyer, Ryan ;
Touch, Sinoeun ;
Wen, Zhiyun ;
Antonello, Joseph ;
Zhang, Lan ;
Flynn, Jessica A. ;
Cox, Kara S. ;
Freed, Daniel C. ;
Vora, Kalpit A. ;
Bahl, Kapil ;
Latham, Andrew H. ;
Smith, Jeffrey S. ;
Gindy, Marian E. ;
Ciaramella, Giuseppe ;
Hazuda, Daria ;
Shaw, Christine A. ;
Bett, Andrew J. .
NPJ VACCINES, 2020, 5 (01)
123456