A Multiomics Atlas of Brown Adipose Tissue Development Over Time

被引：1

作者：

Kumagai, Yutaro ^{[1
]}

Saito, Yutaka ^{[2
,3
]}

Kida, Yasuyuki S. ^{[1
,4
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Cellular & Mol Biotechnol Res Inst, Higashi 1-1-1, Tsukuba, Ibaraki 3058565, Japan

[2] Natl Inst Adv Ind Sci & Technol, Artificial Intelligence Res Ctr, 2-4-7 Aomi,Koto ku, Tokyo 1350064, Japan

[3] AIST Waseda Univ Computat Bio Big Data Open Innova, 3-4-1 Okubo,Shinjuku ku, Tokyo 1698555, Japan

[4] Univ Tsukuba, Sch Integrat & Global Majors, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058572, Japan

来源：

ENDOCRINOLOGY | 2023年 / 164卷 / 06期

关键词：

brown adipose tissue; transcriptome; metabolome; DELTA T-CELLS; ADIPOCYTE DIFFERENTIATION; ENERGY-EXPENDITURE; FAT DEVELOPMENT; EXPRESSION; NEURONS; MOUSE; MICE; PHOSPHORYLATION; METABOLISM;

D O I：

10.1210/endocr/bqad064

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brown adipose tissue (BAT) regulates homeostatic energy balances in response to physiological changes such as nutrition intake, calorie restriction, exercise, and environmental temperature by consuming energy to generate heat, and thus serves as an important organ for obesity and metabolic diseases. We performed an integrated transcriptomic and metabolomic characterization of developing mouse BAT from embryo to adult to obtain a time-resolved picture of BAT development. We demonstrated that there are 2 distinct developmental changes that are BAT specific. We also examined transcription factor binding sites and discovered key transcription factors in the developmental time course. A comparison of our data with other organ development transcriptome and metabolome data revealed BAT-specific transcriptome and metabolome patterns. Our findings provide an overview of mouse BAT development as well as implications for developmental and functional BAT controls.

引用

页数：17

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