A Multiomics Atlas of Brown Adipose Tissue Development Over Time

被引：1
作者：
Kumagai, Yutaro [1 ]
Saito, Yutaka [2 ,3 ]
Kida, Yasuyuki S. [1 ,4 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Cellular & Mol Biotechnol Res Inst, Higashi 1-1-1, Tsukuba, Ibaraki 3058565, Japan
[2] Natl Inst Adv Ind Sci & Technol, Artificial Intelligence Res Ctr, 2-4-7 Aomi,Koto ku, Tokyo 1350064, Japan
[3] AIST Waseda Univ Computat Bio Big Data Open Innova, 3-4-1 Okubo,Shinjuku ku, Tokyo 1698555, Japan
[4] Univ Tsukuba, Sch Integrat & Global Majors, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058572, Japan
来源：
ENDOCRINOLOGY | 2023年 / 164卷 / 06期
关键词：
brown adipose tissue; transcriptome; metabolome; DELTA T-CELLS; ADIPOCYTE DIFFERENTIATION; ENERGY-EXPENDITURE; FAT DEVELOPMENT; EXPRESSION; NEURONS; MOUSE; MICE; PHOSPHORYLATION; METABOLISM;
D O I：
10.1210/endocr/bqad064
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Brown adipose tissue (BAT) regulates homeostatic energy balances in response to physiological changes such as nutrition intake, calorie restriction, exercise, and environmental temperature by consuming energy to generate heat, and thus serves as an important organ for obesity and metabolic diseases. We performed an integrated transcriptomic and metabolomic characterization of developing mouse BAT from embryo to adult to obtain a time-resolved picture of BAT development. We demonstrated that there are 2 distinct developmental changes that are BAT specific. We also examined transcription factor binding sites and discovered key transcription factors in the developmental time course. A comparison of our data with other organ development transcriptome and metabolome data revealed BAT-specific transcriptome and metabolome patterns. Our findings provide an overview of mouse BAT development as well as implications for developmental and functional BAT controls.
引用
收藏
页数：17
相关论文
共 68 条
  • [1] ERRγ Preserves Brown Fat Innate Thermogenic Activity
    Ahmadian, Maryam
    Liu, Sihao
    Reilly, Shannon M.
    Hah, Nasun
    Fan, Weiwei
    Yoshihara, Eiji
    Jha, Pooja
    De Magalhaes Filho, C. Daniel
    Jacinto, Sandra
    Gomez, Andrew V.
    Dai, Yang
    Yu, Ruth T.
    Liddle, Christopher
    Atkins, Annette R.
    Auwerx, Johan
    Saltiel, Alan R.
    Downes, Michael
    Evans, Ronald M.
    [J]. CELL REPORTS, 2018, 22 (11): : 2849 - 2859
  • [2] Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development
    Beauchemin, Kyle J.
    Wells, Julie M.
    Kho, Alvin T.
    Philip, Vivek M.
    Kamir, Daniela
    Kohane, Isaac S.
    Graben, Joel H.
    Bult, Carol J.
    [J]. PEERJ, 2016, 4
  • [3] Brown adipose tissue is associated with cardiometabolic health
    Becher, Tobias
    Palanisamy, Srikanth
    Kramer, Daniel J.
    Eljalby, Mahmoud
    Marx, Sarah J.
    Wibmer, Andreas G.
    Butler, Scott D.
    Jiang, Caroline S.
    Vaughan, Roger
    Schoeder, Heiko
    Mark, Allyn
    Cohen, Paul
    [J]. NATURE MEDICINE, 2021, 27 (01) : 58 - +
  • [4] FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
    Bernardo, Barbara
    Lu, Min
    Bandyopadhyay, Gautam
    Li, Pingping
    Zhou, Yingjiang
    Huang, Jie
    Levin, Nancy
    Tomas, Eva M.
    Calle, Roberto A.
    Erion, Derek M.
    Rolph, Timothy P.
    Brenner, Martin
    Talukdar, Saswata
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [5] Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat
    Beutler, Lisa R.
    Corpuz, Timothy, V
    Ahn, Jamie S.
    Kosar, Seher
    Song, Weimin
    Chen, Yiming
    Knight, Zachary A.
    [J]. ELIFE, 2020, 9 : 1 - 21
  • [6] Global Transcriptome Analysis of Brown Adipose Tissue of Diet-Induced Obese Mice
    Cao, Jingyi
    Zhu, Qi
    Liu, Lin
    Glazier, Bradley J.
    Hinkel, Benjamin C.
    Liang, Chun
    Shi, Haifei
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (04)
  • [7] A metabolomic study of adipose tissue in mice with a disruption of the circadian system
    Castro, C.
    Briggs, W.
    Paschos, G. K.
    FitzGerald, G. A.
    Griffin, J. L.
    [J]. MOLECULAR BIOSYSTEMS, 2015, 11 (07) : 1897 - 1906
  • [8] Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells
    Cavill, Rachel
    Kamburov, Atanas
    Ellis, James K.
    Athersuch, Toby J.
    Blagrove, Marcus S. C.
    Herwig, Ralf
    Ebbels, Timothy M. D.
    Keun, Hector C.
    [J]. PLOS COMPUTATIONAL BIOLOGY, 2011, 7 (03)
  • [9] Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions
    Chae, HD
    Yun, J
    Bang, YJ
    Shin, DY
    [J]. ONCOGENE, 2004, 23 (23) : 4084 - 4088
  • [10] The cellular and functional complexity of thermogenic fat
    Cohen, Paul
    Kajimura, Shingo
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2021, 22 (06) : 393 - 409
1234567