Simple nucleophile/H2O promoted defluorinative ring-opening of gem-difluorocyclopropenes

被引：2

作者：

He, Yimiao ^{[1
]}

Yuan, Jingwen ^{[1
]}

Lv, Wen-Xin ^{[3
]}

Liu, Peng ^{[4
]}

Teng, Fan ^{[5
]}

Mo, Qijin ^{[1
]}

Wu, Zihua ^{[1
]}

Huang, Chusheng ^{[1
]}

Liu, Qianwen ^{[1
]}

Wang, Honggen ^{[2
]}

机构：

[1] Nanning Normal Univ, Coll Chem & Mat, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China

[2] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[3] Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol, Singapore 117543, Singapore

[4] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Peoples R China

[5] Nanchang Hangkong Univ, Persistent Pollutants Control & Resources Recycle, Nanchang 330063, Jiangxi, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2024年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Ring-opening defluorination; 2-Fluoropropenal; 2-Fluorobuta-1; 3-diene; Water; gem-difluorocyclopropene; DIFLUOROCARBENE CHEMISTRY; BOND; DIFLUOROALKENES; ACCESS; ACTIVATION; ACIDS;

D O I：

10.1016/j.gresc.2023.01.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented, providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio- and stereoselectivities. The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents. Water plays a crucial role in this transformation.

引用

页码：14 / 19

页数：6

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