Formulation of an antiseptic topical cream based on chitosan extracted from the scales of the Nile tilapia (Oreochromis niloticus)

The Nile tilapia is a widely consumed fish, its scales dumped in nature as waste have been recovered in the formulation of antiseptic creams because of its high content in chitin, precursor of chitosan. Creams have the advantage of being more comfortable on the skin and allow prolonged administration of the active ingredient. Chitosan is obtained with a yield of 21.2%. FTIR analysis of chitosan showed numerous bands of phase groups present and a successful deacetylation assessed on the intensity of the bands at 1650 cm(-1) and 1315 cm(-1) and confirm by SEM analysis with an abundance of Carbone followed by EDS analysis. Solubilisation of chitosan in 2% acetic acid at 96% and the antibacterial activity test revealed antibacterial activity on Escherichia coli. The viscosity and the optimum spreading capacity of the cream base has been obtained at 14.65% for sesame oil, 9.08% for lanette and 1.26% for glycerine. [GRAPHICS]