Factors Associated With Mortality in Patients With Immune-Mediated Rheumatic Diseases and COVID-19 From Latin America

被引：3

作者：

Ayelen Isnardi, Carolina ^{[1
]}

Alpizar-Rodriguez, Deshire ^{[2
]}

Cerqueira Calderaro, Debora ^{[3
]}

Lopes Marques, Claudia Diniz ^{[4
,5
]}

Javier Pons-Estel, Guillermo ^{[1
]}

Machado Xavier, Ricardo ^{[6
]}

Saurit, Veronica ^{[7
]}

Nora Pisoni, Cecilia ^{[8
]}

Soledad Tissera, Yohana ^{[9
,10
]}

D'Angelo Exeni, Maria Eugenia ^{[10
]}

Alba, Paula ^{[11
]}

Pereira, Dora ^{[12
]}

Andrea Gobbi, Carla ^{[13
]}

Julieta Gamba, Maria ^{[14
]}

Agustina Alfaro, Maria ^{[1
]}

Maria Virasoro, Belen ^{[1
]}

Jazmin Colunga-Pedraza, Iris

Irazoque-Palazuelos, Fedra ^{[16
]}

Reyes-Cordero, Greta ^{[17
]}

Rodriguez-Reyna, Tatiana S. ^{[18
]}

Antonio Veloz-Aranda, Jose ^{[19
]}

Michele Skinner-Taylor, Cassandra ^{[15
]}

Maribel Juarez-Mora, Ingrid ^{[20
]}

Silveira, Luis H. ^{[21
]}

Pacheco Tena, Cesar Francisco ^{[22
]}

Xavier Xibille-Friedmann, Daniel ^{[23
]}

Aparecida Ferreira, Gilda ^{[3
]}

Maria Kakehasi, Adriana ^{[3
]}

Medeiros Pinheiro, Marcelo ^{[24
]}

Monteiro Gomides, Ana Paula ^{[25
]}

Salviato Pileggi, Gecilmara Cristina ^{[24
]}

Henrique da Mota, Licia Maria ^{[26
]}

Torres dos Reis-Neto, Edgard ^{[24
]}

Euzebio Ribeiro, Sandra Lucia ^{[27
]}

de Azevedo Valadares, Lilian David ^{[28
]}

Ulises Martinez-Martinez, Marco ^{[29
]}

机构：

[1] Argentine Soc Rheumatol, Res Unit, Buenos Aires, DF, Argentina

[2] Colegio Mexicano Reumatol, Res Unit, Mexico City, DF, Mexico

[3] Univ Fed Minas Gerais, Med Sch, Locomotor Syst Dept, Belo Horizonte, MG, Brazil

[4] Univ Fed Pernambuco, Area Acad Med Clin, Recife, PE, Brazil

[5] Hosp Clin UFPE Ebserh, Recife, PE, Brazil

[6] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

[7] Hosp Privado Univ Cordoba, Cordoba, Argentina

[8] Ctr Educ Med & Invest Clin, Buenos Aires, Argentina

[9] Hosp Cordoba, Unidad Reumatol, Serv Clin Med, Cordoba, Argentina

[10] Sanat Parque, Cordoba, Argentina

[11] FMC Univ Nacl Cordoba, Rheumatol Unit, Catedra Semiol, Hosp Cordoba & Materno Neonatal, Cordoba, Argentina

[12] Raquis, La Plata, Buenos Aires, Argentina

[13] UNC, Hosp Cordoba, Catedra Clin Med 1, FCM, Cordoba, Argentina

[14] Hosp Nacl Alejandro Posadas, Buenos Aires, Argentina

[15] Hosp Univ Jose Eleuterio Gonzalez, UANL, Monterrey, Mexico

[16] Ctr Invest & Tratamiento Reumatol SC, Rheumatol, Mexico City, DF, Mexico

[17] Univ Autonoma Chihuahua, Fac Med & Ciencias Biomed, Chihuahua, Mexico

[18] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, DF, Mexico

[19] Hosp Reg ISSSTE, Leon, Mexico

[20] Inst Mexicano Seguro Social, Internal Med, Mexico City, DF, Mexico

[21] Inst Nacl Cardiol Ignacio Chavez City, Mexico City, DF, Mexico

[22] Univ Autonoma Chihuahua, Fac Med & Ciencias Biomed, Chihuahua, Chihuahua, Mexico

[23] Hosp Gen Cuernavaca Dr Jose G Parres, Dept Reumatol, Cuernavaca, Mexico

[24] Univ Fed Sao Paulo UNIFESP EPM, Dept Med, Rheumatol Div, Escola Paulista Med, Sao Paulo, Brazil

[25] UniCEUB, Med Sch, Rheumatol Dept, Brasilia, DF, Brazil

[26] Univ Brasilia, Programa Posgrad Patol Mol, Hosp Univ Brasilia, Programa Posgrad Ciencias Med,Fac Med, Brasilia, DF, Brazil

[27] Univ Fed Amazonas, Med Sch, Manaus, Amazonas, Brazil

[28] Hosp Getulio Vargas, Recife, PE, Brazil

[29] Hosp Gen Subzona 9, Inst Mexicano Seguro Social, Fray Juan Bautista de Mollinedo 423, Rioverde 79610, San Luis Potosi, Mexico

来源：

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY | 2024年 / 30卷 / 01期

关键词：

COVID-19; epidemiology; rheumatic immune-mediated inflammatory diseases; SARS-CoV-2; infection; COHORT;

D O I：

10.1097/RHU.0000000000002038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveTo describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, and to assess factors associated with mortality in this population.MethodsData from 3 national registries, SAR-COVID (Argentina), CMR-COVID (Mexico), and ReumaCoV-Brasil (Brazil), were combined. Adult patients with IMIDs and SARS-CoV-2 infection were recruited. Sociodemographic data, comorbidities, IMID clinical characteristics and treatment, and SARS-CoV-2 infection presentation and outcomes were recorded.ResultsA total of 4827 individuals were included: 2542 (52.7%) from SAR-COVID, 1167 (24.2%) from CMR-COVID, and 1118 (23.1%) from ReumaCoV-Brasil. Overall, 82.1% were female with a mean age of 49.7 (SD, 14.3) years; 22.7% of the patients were hospitalized, and 5.3% died because of COVID-19 (coronavirus disease 2019). Argentina and Brazil had both 4% of mortality and Mexico 9.4%. In the multivariable analysis, older age (>= 60 years; odds ratio [OR], 7.4; 95% confidence interval [CI], 4.6-12.4), male sex (OR, 1.5; 95% CI, 1.1-2.1), living in Mexico (OR, 3.0; 95% CI, 2.0-4.4), comorbidity count (1 comorbidity: OR, 1.5; 95% CI, 1.0-2.1), diagnosis of connective tissue disease or vasculitis (OR, 1.8; 95% CI, 1.3-2.4), and other diseases (OR, 2.6; 95% CI, 1.6-4.1) compared with inflammatory joint disease, high disease activity (OR, 4.2; 95% CI, 2.5-7.0), and treatment with glucocorticoids (OR, 1.9; 95% CI, 1.4-2.5) or rituximab (OR, 4.2; 95% CI, 2.7-6.6) were associated with mortality.ConclusionsMortality in patients with IMIDs was particularly high in Mexicans. Ethnic, environmental, societal factors, and different COVID-19 mitigation measures adopted have probably influenced these results.

引用

页码：E9 / E17

页数：9

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