The potential role of stem cells-derived extracellular vesicles in the treatment of musculoskeletal system diseases

被引：1
作者：
Li, Zhuo [1 ]
Hou, Demiao [1 ]
Tang, Zijin [1 ]
Xiong, Lishun [1 ]
Yan, Yiguo [1 ,2 ]
机构：
[1] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Spine Surg, Hengyang, Hunan, Peoples R China
[2] Univ South China, Affiliated Hosp 1, Dept Spine Surg, Hengyang 421001, Hunan, Peoples R China
来源：
CELL BIOLOGY INTERNATIONAL | 2024年 / 48卷 / 03期
基金：
中国国家自然科学基金;
关键词：
extracellular vesicles; musculoskeletal system diseases; stem cells; therapeutic carriers; INTERVERTEBRAL DISC DEGENERATION; SKELETAL-MUSCLE; PROGENITOR CELLS; EXOSOMES; DIFFERENTIATION; MICROVESICLES; INFLAMMATION; REGENERATION; TENDON; OSTEOARTHRITIS;
D O I：
10.1002/cbin.12107
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The therapeutic potential of stem cells-derived extracellular vesicles (EVs) has shown a great progress in the regenerative medicine. EVs are rich in a variety of bioactive substances, which are important carriers of signal transmission and interactions between cells, and they play an important role in the processes of tissue repair and regeneration. Several studies have shown that stem cells-derived EVs regulate immunity, promote cell proliferation and differentiation, enhance bone and vascular regeneration, and play an increasingly important role in musculoskeletal system. This review aimed to describe the biological characteristics of stem cells-derived EVs and discuss their potential role in the therapy of musculoskeletal system diseases.
引用
收藏
页码：237 / 252
页数：16
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