Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study

被引：0

作者：

Correa, Thiago Domingos ^{[1
,2
]}

Midega, Thais Dias ^{[1
]}

Cordioli, Ricardo Luiz ^{[1
]}

Barbas, Carmen Silvia Valente ^{[1
]}

Filho Roberto, Rabello ^{[1
]}

Silva, Bruno Caldin da ^{[1
]}

Silva Junior, Moacyr ^{[1
]}

Nawa, Ricardo Kenji ^{[1
]}

de Carvalho, Fabricio Rodrigues Torres ^{[1
]}

de Matos, Gustavo Faissol Janot ^{[1
]}

Lucinio, Neide Marcela ^{[1
]}

Rodrigues, Rodrigo Dias ^{[1
]}

Eid, Raquel Afonso Caserta ^{[1
]}

Bravim, Bruno de Arruda ^{[1
]}

Pereira, Adriano Jose ^{[1
]}

Santos, Bento Fortunato Cardoso dos ^{[1
]}

Pinho, Joao Renato Rebello ^{[1
]}

Pardini, Andreia ^{[1
]}

Teich, Vanessa Damazio ^{[1
]}

Laselva, Claudia Regina ^{[1
]}

Neto, Miguel Cendoroglo ^{[1
]}

Klajner, Sidney ^{[1
]}

Ferraz, Leonardo Jose Rolim ^{[1
]}

机构：

[1] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil

[2] Ave Albert Einstein,627-701,5th floor Morumbi, BR-05652900 Sao Paulo, SP, Brazil

来源：

EINSTEIN-SAO PAULO | 2023年 / 21卷

关键词：

Coronavirus infections; COVID-19; SARS-CoV-2; Respiration; artificial; Noninvasive ventilation; Extracorporeal membrane oxygenation; Critical care outcomes; Mortality; Intensive care units; MORTALITY; MORBIDITY; MODEL;

D O I：

10.31744/einstein_journal/2023AO0233

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. Methods: In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor System; all adult patients admitted to the intensive care unit between March 4, 2020, and October 1, 2021, were included in the study. We compared the clinical characteristics and outcomes of patients admitted to the intensive care unit of a quaternary private hospital in Sao Paulo, Brazil, during the first (May 1, 2020, to August 31, 2020) and second (March 1, 2021, to June 30, 2021) waves of the COVID-19 pandemic. Results: In total, 1,427 patients with COVID-19 were admitted to the intensive care unit during the first (421 patients) and second (1,006 patients) waves. Compared with the first wave group [median (IQR)], the second wave group was younger [57 (46-70) versus 67 (52-80) years; p<0.001], had a lower SAPS 3 Score [45 (42-52) versus 49 (43-57); p<0.001], lower SOFA Score on intensive care unit admission [3 (1-6) versus 4 (2-6); p=0.018], lower Charlson Comorbidity Index [0 (0-1) versus 1 (0-2); p<0.001], and were less frequently frail (10.4% versus 18.1%; p<0.001). The second wave group used more noninvasive ventilation (81.3% versus 53.4%; p<0.001) and high-flow nasal cannula (63.2% versus 23.0%; p<0.001) during their intensive care unit stay. The intensive care unit (11.3% versus 10.5%; p=0.696) and in-hospital mortality (12.3% versus 12.1%; p=0.998) rates did not differ between both waves. Conclusion: In the first and second waves, patients with severe COVID-19 exhibited similar mortality rates and need for invasive organ support, despite the second wave group being younger and less severely ill at the time of intensive care unit admission.

引用

页数：10

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