Formation of a novel Cu-containing bioactive glass nano-topography coating with strong bactericidal capability and bone regeneration

被引：38

作者：

Huo, Shicheng ^{[1
]}

Lyu, Zhuocheng ^{[2
]}

Su, Xinjin ^{[3
]}

Wang, Fan ^{[7
]}

Liu, Jia ^{[1
]}

Liu, Shu ^{[1
]}

Liu, Xuesong ^{[8
]}

Bao, Xiaogang ^{[1
]}

Zhang, Jue ^{[6
]}

Zheng, Kai ^{[4
,5
]}

Xu, Guohua ^{[1
]}

机构：

[1] Navy Med Univ, Changzheng Hosp, Spine Ctr, Dept Orthoped Surg, Shanghai 200003, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Bone & Joint Surg,Dept Orthoped, Shanghai 200127, Peoples R China

[3] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Spine Surg, Shanghai 200127, Peoples R China

[4] Nanjing Med Univ, Jiangsu Prov Engn Res Ctr Stomatol Translat Med, Nanjing 210029, Peoples R China

[5] Nanjing Med Univ, Jiangsu Key Lab Oral Dis, Nanjing 210029, Peoples R China

[6] Wannan Med Coll Wuhu, Oral Dis Res Ctr, Sch Stomatol, Wuhu 241000, Peoples R China

[7] East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

[8] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Rheumatol, 145 Middle Shandong Rd, Shanghai 200001, Peoples R China

来源：

COMPOSITES PART B-ENGINEERING | 2023年 / 253卷

基金：

中国国家自然科学基金;

关键词：

Electrophoretic deposition; Copper; Immunomodulation; Antibacterial; Osseointegration; ELECTROPHORETIC DEPOSITION; ANTIBACTERIAL; AGENT; FACILITATE; CYTOKINES; CHITOSAN; ZINC;

D O I：

10.1016/j.compositesb.2023.110521

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Implant-related infection (IRI) is a disastrous complication after total joint arthroplasty (TJA). Due to its cyto-compatibility and mechanically resistance, titanium (Ti) has been recognized as suitable bone implant materials. However, Ti lacks bioactivity and is vulnerable to bacterial infection. In this study, we developed an innovative surface coating using electrophoretic deposition (EPD) to overcome those limitations. The coating was composed of (i) a natural biocompatibility polymer Chitosan (Chit), and (ii) a novel copper-doped bioactive glass nano -particles (Cu-BGNs) with antibacterial and pro-osteogenic properties. In vitro experiments showed that this coating endowed the Ti surface with the ability to promote macrophage M1 polarization through topography cues and released copper ions. The coating combining immunoregulatory antibacterial effects with transient bactericidal activity led to synergetic effects against IRIs. Furthermore, the coated Ti implants exerted favorable osteo-immunomodulatory effects towards enhanced osteogenic abilities as evidenced in vitro and in vivo. This strategy combining Cu-BGNs-Chit composites and EPD provides novel strategies for designing and fabricating immunomodulatory implants targeting IRIs.

引用

页数：16

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