Effect of Ajwa date pits powder (Phoenix dactylifera L.) on body composition, lipid profile and blood pressure in patients with hyperlipidemia: A randomized clinical trial

被引:0
|
作者
Nasrullah, Parkha Riaz [1 ]
Sehar, Bismillah [2 ]
Safdar, Mahpara [3 ]
Fatima, Sadia [4 ]
Zeb, Falak [5 ]
Shah, Jahan [6 ]
Khalil, Atif Ali Khan [7 ]
Ahmed, Bilal [8 ]
Alsubaie, Ali Saad R. [9 ]
Zaman, Muhammad Haidar [1 ,10 ]
机构
[1] Univ Agr Peshawar, Dept Human Nutr, Peshawar, Pakistan
[2] Univ Bedfordshire, Dept Hlth & Social Sci, Luton, England
[3] Allama Iqbal Open Univ Islamabad, Fac Sci, Dept Environm Design Hlth & Nutr Sci, Islamabad, Pakistan
[4] Khyber Med Univ, Dept Biochem, Peshawar, Pakistan
[5] Univ Sharjah, Sharjah Inst Med Res, Sharjah, U Arab Emirates
[6] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China
[7] Lahore Coll Women Univ, Fac Pharmaceut & Allied Hlth Sci, Dept Pharmacognosy, Lahore, Pakistan
[8] Nanjing Med Univ, Sch Pharm, Dept Pharmacol, Nanjing, Jiangsu, Peoples R China
[9] Imam Abdulrahman Bin Faisal Univ, Coll Publ Hlth, Dept Publ Hlth, Dammam, Saudi Arabia
[10] Nanjing Normal Univ, Nan Shi Fu Zhong NSFZ, Nanjing, Peoples R China
关键词
Ajwa dates pit powder; Hyperlipidemia; Body composition; Systolic blood pressure; ANTIOXIDANT ACTIVITY; CHOLESTEROL; FRUITS; ANTIOBESITY; CONSUMPTION; VARIETIES; EXTRACT; GLUCOSE; SEEDS;
D O I
10.22038/AJP.2022.21316
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Objective: To evaluate the effect of Ajwa dates pit powder (ADP) on lipid profile, body composition and blood pressure in patients with hyperlipidemia. Materials and Methods: This randomized controlled clinical study was carried out on 40 patients with total cholesterol >200 mg/dl, triglycerides >150 mg/dl and BMI >25, of either sex, aged 30-50 years, who were recruited through written consent. The patients were divided into two groups (n=20 each): the ADP and the control group (CG). All patients received the doctor's prescribed class A statin (Rosuvastatin/ Atorvastatin) 10 mg/day, while 2.7 g ADP was given on daily basis before breakfast with lukewarm water for 40 days and the control group received the same amount of wheat flour. Body composition, blood pressure and lipid profile were determined at baseline, and after 20 and 40 days. Data were analyzed by using SPSS and GraphPad Prism. Results: ADP significantly reduced body weight (p<0.001), BMI (p<0.001), fat mass, body fat percentage, visceral fat area and waist circumference compared to the control group. Similarly, ADP significantly (p=0.000) decreased the serum level of total cholesterol and low-density lipoprotein. Conclusion: ADP may have the potential to improve dyslipidemia and obesity.
引用
收藏
页码:143 / 152
页数:10
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