Diagnosis by metagenomic next-generation sequencing of invasive pulmonary aspergillosis in an infant with chronic granulomatous disease

被引：2

作者：

Yang, Aimei ^{[1
]}

Wang, Chun ^{[1
]}

Chen, Peiling ^{[1
]}

Zheng, Guilang ^{[1
]}

Zhao, Zhenjun ^{[2
]}

Liu, Jian ^{[3
]}

Zhang, Jingwen ^{[1
]}

Wang, Jing ^{[1
]}

Sun, Yueyu ^{[1
]}

Yang, Juhua ^{[4
]}

Guo, Yuxiong ^{[1
,5
]}

机构：

[1] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Intens Care Unit, Dept Pediat, Guangzhou, Peoples R China

[2] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Radiol, Guangzhou, Peoples R China

[3] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Pathol, Guangzhou, Peoples R China

[4] Vis Med Co Ltd, Guangzhou, Peoples R China

[5] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Intens Care Unit, Dept Pediat, Guangzhou 510080, Peoples R China

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2023年 / 41卷

关键词：

Aspergillus fumigatus; Chronic granulomatous disease; Bronchoalveolar lavage fluid; Metagenomic next-generation sequencing; Case report; CLINICAL UTILITY; FUNGAL DISEASES; GALACTOMANNAN; CHILDREN; SERUM; PERFORMANCE; CASPOFUNGIN; FEATURES;

D O I：

10.1016/j.rmcr.2022.101792

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Invasive pulmonary aspergillosis (IPA) is a serious fungal infection, with a high degree of mortal-ity in immunocompromised individuals. Diagnosis of IPA is challenging in that clinical manifesta-tions are not specific, with sensitivity of traditional detection procedures low. We report a case of IPA in a chronic granulomatous disease (CGD) infant who was initially suspected to have a lung tumor. Aspergillus fumigatus was identified as the pathogen in bronchoalveolar lavage fluid (BALF) by next-generation sequencing (mNGS). The patient recovered rapidly following a change of appropriate antifungal treatment and was discharged. This case highlights the additional value of BALF-mNGS for the diagnosis of pediatric invasive pulmonary fungal infection in immune -deficient children.

引用

页数：6

共 28 条

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