Psychological stress: neuroimmune roles in periodontal disease

被引：12

作者：

Zhang, Jiayao ^{[1
]}

Lin, Shuxian ^{[1
]}

Luo, Lijun ^{[2
]}

Zhang, Qi ^{[3
,4
]}

Jiao, Yi ^{[1
]}

Liu, Weicai ^{[1
]}

机构：

[1] Tongji Univ, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Dept Prosthodont, Stomatol Hosp & Dent Sch, Shanghai, Peoples R China

[2] Tongji Univ, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Dept Periodontol, Stomatol Hosp & Dent Sch, Shanghai, Peoples R China

[3] East China Normal Univ, Affiliated Mental Hlth Ctr ECNU, Sch Psychol & Cognit Sci, Shanghai Key Lab Brain Funct Genom,Minist Educ, Shanghai 200062, Peoples R China

[4] Shanghai Changning Mental Hlth Ctr, Shanghai 200335, Peoples R China

来源：

ODONTOLOGY | 2023年 / 111卷 / 03期

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

Psychological stress; Periodontal disease; Psychoneuroimmune; GINGIVAL CREVICULAR FLUID; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; SUBSTANCE-P; CHROMOGRANIN-A; MOLECULAR-MECHANISMS; DEPRESSION; BRAIN; NOREPINEPHRINE; NEUROPEPTIDES; INFLAMMASOME;

D O I：

10.1007/s10266-022-00768-8

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Periodontitis is a chronic inflammatory disease that starts with pathogenic bacteria and is mediated by a combination of multiple factors. Psychosomatic factors are considered to be one of the most critical risk factors for periodontal disease. Psychological stress may threaten periodontal immune homeostasis in multiple ways by affecting the hypothalamic-pituitary-adrenal cortex system, the locus ceruleus-sympathetic-adrenal medulla system, and the peptidergic nervous system. In this review, we outline the complex role of psychological stress in promoting the development of periodontal disease, focusing on the effects of stress on flora metabolism, tissue inflammation, and alveolar bone homeostasis. At the same time, we broadly and deeply summarize the potential mechanisms of psychological stress-induced periodontal disease, emphasize the importance of neuroimmune modulation for periodontal health, and expect to provide a new perspective for periodontal science based on psychoneuroimmunology.

引用

页码：554 / 564

页数：11

共 110 条

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