PEG-mediated synthesis, antibacterial, antifungal and antioxidant studies of some new 1,3,5-trisubstituted 2-pyrazolines

被引：12
作者：
Dhonnar, Sunil L. [1 ]
Jagdale, Bapu S. [1 ]
Adole, Vishnu A. [1 ]
Sadgir, Nutan, V [1 ]
机构：
[1] Panchavati Savitribai Phule Pune Univ, Dept Chem, Mahatma Gandhi Vidyamandirs Loknete Vyankatrao Hi, Nasik 422003, India
来源：
MOLECULAR DIVERSITY | 2023年 / 27卷 / 06期
关键词：
Pyrazolines; Antimicrobial; Antioxidant; PEG solvent; Azoles; POLYETHYLENE-GLYCOL PEG-400; GREEN REACTION MEDIUM; PYRAZOLINE DERIVATIVES; EFFICIENT SYNTHESIS; ANTIMICROBIAL ACTIVITY; ONE-POT; ARYLMETHYLIDENEPYRUVIC ACIDS; CYCLOCONDENSATION REACTION; OXIDATIVE STRESS; CHALCONES;
D O I：
10.1007/s11030-022-10562-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of 1,3,5-trisubstituted 2-pyrazoline derivatives (3a-l) are synthesized in good to excellent yields from the corresponding chalcones (1a-h) and acid hydrazides (2a-e) in polyethylene glycol-400 (PEG-400) as a green reaction medium. The newly synthesized 2-pyrazoline derivatives are screened for their antibacterial and antifungal activity. The synthesized trisubstituted pyrazolines displayed moderate to good antibacterial and antifungal properties as compared with the standard reference penicillin and fluconazole drugs. Additionally, the antioxidant potential of the 1,3,5-trisubstituted 2-pyrazolines is evaluated by OH and DPPH assay. The 1,3,5-trisubstituted 2-pyrazolines showed good radical scavenger activity and were found as good antioxidant agents.
引用
收藏
页码：2441 / 2452
页数：12
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