The IGF2BP2-lncRNA TRPC7-AS1 axis promotes hepatocellular carcinoma cell proliferation and invasion

被引：4
作者：
Zhang, Xu [2 ]
Li, Zilin [2 ]
Nie, Huizong [2 ]
Huang, Yue [2 ]
Du, Jingyang [2 ]
Xi, Yiling [2 ]
Guo, Chaoqin [2 ]
Mu, Mingshan [2 ]
Li, Xiangyu [2 ]
Zheng, Xiaoliang [1 ,2 ,3 ,4 ]
Xu, Qiuran [1 ,2 ,4 ]
Huang, Dongsheng [1 ,2 ]
Tu, Linglan [1 ,4 ]
Cheng, Liyan [1 ,3 ,4 ]
机构：
[1] Hangzhou Med Coll, Sch Lab Med & Bioengn, Hangzhou, Zhejiang, Peoples R China
[2] Hangzhou Med Coll, Sch Basic Med & Forens Med, Hangzhou, Zhejiang, Peoples R China
[3] Hangzhou Med Coll, Zhejiang Prov Lab Expt Anim & Nonclin Lab Studies, 182 Tianmushan Rd, Hangzhou City, Zhejiang Provin, Peoples R China
[4] Zhejiang Key Lab Tumor Mol Diag & Individualized M, Hangzhou, Peoples R China
来源：
CELLULAR SIGNALLING | 2024年 / 117卷
关键词：
IGF2BP2; TRPC7-AS1; Hepatocellular carcinoma; Proliferation; Invasion; EXPRESSION; GROWTH;
D O I：
10.1016/j.cellsig.2024.111078
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hepatocellular carcinoma(HCC) is one of the most common tumors in the world. Human insulin-like growth factor 2(IGF2) mRNA binding protein 2(IGF2BP2) plays an important role in the progression of hepatocellular carcinoma. Additionally, long non-coding RNA(lncRNA) has been confirmed as a key regulator of hepatocellular carcinoma occurrence. However, the function of TRPC7-AS1 has not been verified in hepatocellular carcinoma. The research results revealed that high IGF2BP2 expression was associated with a decreased survival rate in patients with hepatocellular carcinoma. Furthermore, IGF2BP2 knockdown inhibited and IGF2BP2 overexpression promoted the cell proliferation and invasion of hepatocellular carcinoma cells. The research illuminated that IGF2BP2 regulated the expression of TRPC7-AS1, and a correlation was observed between IGF2BP2 and TRPC7-AS1 expression. TRPC7-AS1 silencing repressed and its overexpression promoted the progression of hepatocellular carcinoma. After silencing or overexpressing TRPC7-AS1, the expression of the high-mobility group AT-hook 2 (HMGA2) gene decreased or increased, respectively. IGF2BP2 enhanced the expression of TRPC7-AS1 and thus affected the expression of HMGA2, thereby promoting hepatocellular carcinoma progression.
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页数：10
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