Towards a Global View of Parkinson's Disease Genetics

被引：7

作者：

Khani, Marzieh ^{[2
,3
]}

Cerquera-Cleves, Catalina ^{[4
,5
]}

Kekenadze, Mariam ^{[6
,7
]}

Crea, Peter Wild ^{[2
,3
]}

Singleton, Andrew B. ^{[2
,3
]}

Bandres-Ciga, Sara ^{[1
,2
,3
]}

机构：

[1] NIA, NIH, Ctr Alzheimers Dis & Related Dementias CARD, 9000 Rockville Pike,NIH Bldg T44, Bethesda, MD 20892 USA

[2] NIA, Ctr Alzheimers & Related Dementias CARD, Bethesda, MD USA

[3] NINDS, NIH, Bethesda, MD USA

[4] Pontificia Univ Javeriana, San Ignacio Hosp, Neurol Unit, Bogota, Colombia

[5] Laval Univ, CHU Quebec Res Ctr, Axe Neurosci, Quebec City, PQ, Canada

[6] Tbilisi State Med Univ, Tbilisi, Georgia

[7] UCL, Queen Sq Inst Neurol, London, England

来源：

ANNALS OF NEUROLOGY | 2024年 / 95卷 / 05期

基金：

美国国家卫生研究院;

关键词：

ALPHA-SYNUCLEIN; LRRK2; G2019S; GLUCOCEREBROSIDASE MUTATIONS; ASHKENAZI JEWS; PENETRANCE; RISK; PHENOTYPE; FREQUENCY; VPS35; DUPLICATION;

D O I：

10.1002/ana.26905

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non-European populations has revealed novel population-specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which is crucial for developing disease-modifying interventions. This review comprehensively explores the global genetic landscape of PD, emphasizing the scientific rationale for studying underrepresented populations. It underscores challenges, such as genotype-phenotype heterogeneity and inclusion difficulties for non-European participants, emphasizing the ongoing need for diverse and inclusive research in PD. ANN NEUROL 2024

引用

页码：831 / 842

页数：12

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