Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JS']JSCCR database in Japan

被引：1

作者：

Yamashita, Ken ^{[1
]}

Oka, Shiro ^{[1
]}

Yamada, Takeshi ^{[2
]}

Mitsui, Keigo ^{[3
]}

Yamamoto, Hironori ^{[4
]}

Takahashi, Keiichi ^{[5
]}

Shiomi, Akio ^{[6
]}

Hotta, Kinichi ^{[7
]}

Takeuchi, Yoji ^{[8
]}

Kuwai, Toshio ^{[9
]}

Ishida, Fumio ^{[10
]}

Kudo, Shin-Ei ^{[10
]}

Saito, Shoichi ^{[11
]}

Ueno, Masashi ^{[12
]}

Sunami, Eiji ^{[13
]}

Yamano, Tomoki ^{[14
]}

Itabashi, Michio ^{[15
]}

Ohtsuka, Kazuo ^{[16
]}

Kinugasa, Yusuke ^{[17
]}

Matsumoto, Takayuki ^{[18
]}

Sugai, Tamotsu ^{[19
]}

Uraoka, Toshio ^{[20
]}

Kurahara, Koichi ^{[21
]}

Yamaguchi, Shigeki ^{[22
]}

Kato, Tomohiro ^{[23
]}

Okajima, Masazumi ^{[24
]}

Kashida, Hiroshi ^{[25
]}

Akagi, Yoshito ^{[26
]}

Ikematsu, Hiroaki ^{[27
]}

Ito, Masaaki ^{[28
]}

Esaki, Motohiro ^{[29
]}

Kawai, Masaya ^{[30
]}

Yao, Takashi ^{[31
]}

Hamada, Madoka ^{[32
]}

Horimatsu, Takahiro ^{[33
]}

Koda, Keiji ^{[34
]}

Fukai, Yasumori ^{[35
]}

Komori, Koji ^{[36
]}

Saitoh, Yusuke ^{[37
]}

Kanemitsu, Yukihide ^{[38
]}

Takamaru, Hiroyuki ^{[39
]}

Yamada, Kazutaka ^{[40
]}

Nozawa, Hiroaki ^{[41
]}

Takayama, Tetsuji ^{[42
]}

Togashi, Kazutomo ^{[43
]}

Shinto, Eiji ^{[44
]}

Torisu, Takehiro ^{[45
]}

Toyoshima, Akira ^{[46
]}

Ohmiya, Naoki ^{[47
]}

Kato, Takeshi ^{[48
]}

机构：

[1] Hiroshima Univ Hosp, Dept Gastroenterol, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348551, Japan

[2] Nippon Med Sch, Dept Gastrointestinal Hepatobiliary Pancreat Surg, Tokyo, Japan

[3] Nippon Med Sch, Grad Sch Med, Dept Gastroenterol, Tokyo, Japan

[4] Jichi Med Univ, Dept Med, Div Gastroenterol, Tochigi, Japan

[5] Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Colorectal Surg, Tokyo, Japan

[6] Shizuoka Canc Ctr, Div Colon & Rectal Surg, Shizuoka, Japan

[7] Shizuoka Canc Ctr, Div Endoscopy, Shizuoka, Japan

[8] Osaka Int Canc Inst, Dept Gastrointestinal Oncol, Osaka, Japan

[9] Natl Hosp Org Kure Med Ctr, Dept Gastroenterol, Hiroshima, Japan

[10] Showa Univ, Northern Yokohama Hosp, Digest Dis Ctr, Kanagawa, Japan

[11] Japanese Fdn Canc Res, Dept Lower Gastrointestinal Med, Canc Inst Hosp, Tokyo, Japan

[12] Toranomon Gen Hosp, Dept Gastroenterol Surg, Tokyo, Japan

[13] Kyorin Univ, Sch Med, Dept Surg, Tokyo, Japan

[14] Hyogo Coll Med, Dept Surg, Div Lower Gastrointestinal Surg, Nishinomiya, Hyogo, Japan

[15] Tokyo Womens Med Univ, Inst Gastroenterol, Dept Surg, Tokyo, Japan

[16] Tokyo Med & Dent Univ, Dept Gastroenterol & Hepatol, Tokyo, Japan

[17] Tokyo Med & Dent Univ, Dept Gastrointestinal Surg, Tokyo, Japan

[18] Iwate Med Univ, Dept Internal Med, Div Gastroenterol, Morioka, Iwate, Japan

[19] Iwate Med Univ, Dept Diagnost Pathol, Yahaba, Iwate, Japan

[20] Gunma Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Gunma, Japan

[21] Matsuyama Red Cross Hosp, Div Gastroenterol, Matsuyama, Ehime, Japan

[22] Saitama Med Univ, Int Med Ctr, Dept Gastroenterol Surg, Saitama, Japan

[23] Jikei Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo, Japan

[24] Hiroshima City Hiroshima Citizens Hosp, Dept Surg, Hiroshima, Japan

[25] Kindai Univ, Dept Gastroenterol & Hepatol, Fac Med, Osaka, Japan

[26] Kurume Univ, Sch Med, Dept Surg, Fukuoka, Japan

[27] Natl Canc Ctr Hosp East, Dept Gastroenterol & Endoscopy, Chiba, Japan

[28] Natl Canc Ctr Hosp East, Dept Colorectal Surg, Chiba, Japan

[29] Saga Univ, Fac Med, Dept Internal Med, Div Gastroenterol, Saga, Japan

[30] Juntendo Univ, Fac Med, Dept Coloproctol Surg, Tokyo, Japan

[31] Juntendo Univ, Grad Sch Med, Dept Human Pathol, Tokyo, Japan

[32] Kansai Med Univ Hosp, Dept Gastrointestinal Surg, Osaka, Japan

[33] Kyoto Univ Hosp, Dept Clin Oncol, Kyoto, Japan

[34] Teikyo Univ, Chiba Med Ctr, Dept Surg, Chiba, Japan

[35] Maebashi Red Cross Hosp, Dept Gastroenterol, Gunma, Japan

[36] Aichi Canc Ctr Hosp, Dept Gastroenterol Surg, Aichi, Japan

[37] Asahikawa City Hosp, Dept Gastroenterol, Asahikawa, Hokkaido, Japan

[38] Natl Canc Ctr, Dept Colorectal Surg, Tokyo, Japan

[39] Natl Canc Ctr, Div Endoscopy, Tokyo, Japan

[40] Takano Hosp, Dept Surg, Coloproctol Ctr, Kumamoto, Japan

[41] Univ Tokyo, Dept Surg Oncol, Tokyo, Japan

[42] Tokushima Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Oncol, Tokushima, Japan

[43] Fukushima Med Univ, Aizu Med Ctr, Dept Coloproctol, Fukushima, Japan

[44] Natl Def Med Coll, Dept Surg, Tokorozawa, Saitama, Japan

[45] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan

[46] Japanese Red Cross Med Ctr, Dept Colorectal Surg, Tokyo 1508935, Japan

[47] Fujita Hlth Univ, Sch Med, Dept Adv Endoscopy, Toyoake, Aichi, Japan

[48] Natl Hosp Org Osaka Natl Hosp, Dept Surg, Osaka, Japan

[49] Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, Kyoto, Japan

[50] Hiroshima City North Med Ctr Asa Citizens Hosp, Dept Gastroenterol, Hiroshima, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2024年 / 59卷 / 05期

关键词：

Primary small bowel adenocarcinoma; Capsule endoscopy; Double-balloon endoscopy; Lynch syndrome; Prognosis; SMALL-INTESTINE; CAPSULE ENDOSCOPY; CANCER; SURVIVAL; EPIDEMIOLOGY; DIAGNOSIS;

D O I：

10.1007/s00535-024-02081-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundThe clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan.MethodsWe analyzed 354 patients with 358 PSBAs, between January 2008 and December 2017, at 44 institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum.ResultsThe median age was 67 years (218 males, 61.6%). The average tumor size was 49.9 (7-100) mm. PSBA sites consisted of jejunum (66.2%) and ileum (30.4%). A total of 219 patients (61.9%) underwent diagnostic small bowel endoscopy, including single-balloon endoscopy, double-balloon endoscopy, and capsule endoscopy before treatment. Nineteen patients (5.4%) had Lynch syndrome, and 272 patients (76.8%) had symptoms at the initial diagnosis. The rates for stages 0, I, II, III, and IV were 5.4%, 2.5%, 27.1%, 26.0%, and 35.6%, respectively. The 5-year overall survival rates at each stage were 92.3%, 60.0%, 75.9%, 61.4%, and 25.5%, respectively, and the 5-year disease-specific survival (DSS) rates were 100%, 75.0%, 84.1%, 59.3%, and 25.6%, respectively. Patients with the PSBA located in the jejunum, with symptoms at the initial diagnosis or advanced clinical stage had a worse prognosis. However, multivariate analysis using Cox-hazard model revealed that clinical stage was the only significant predictor of DSS for patients with PSBA.ConclusionsOf the patients with PSBA, 76.8% had symptoms at the initial diagnosis, which were often detected at an advanced stage. Detection during the early stages of PSBA is important to ensure a good prognosis.

引用

页码：376 / 388

页数：13

共 47 条

[21] An analysis of clinicopathological features and prognosis by comparing hepatoid adenocarcinoma of the stomach with AFP-producing gastric cancer
Liu, Xiaowen
Sheng, Weiqi
Wang, Yanong
JOURNAL OF SURGICAL ONCOLOGY, 2012, 106 (03) : 299 - 303
[22] Primary small-bowel non-Hodgkin's lymphoma: a study of clinical features, pathology, management and prognosis
Yin, L.
Chen, C. Q.
Peng, C. H.
Chen, G. M.
Zhou, H. J.
Han, B. S.
Li, H. W.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2007, 35 (03) : 406 - 415
[23] Clinical features and prognosis of primary tracheal small cell carcinoma: a population-based analysis
Chen, Kun
Yang, Zhihao
Zhang, Xinbo
Zhao, Tianhao
Zhang, Xiang
Li, Wenfeng
Yu, Shanshan
Xie, Deyao
He, Zhifeng
Cheng, Dezhi
TRANSLATIONAL CANCER RESEARCH, 2020, 9 (02) : 882 - 890
[24] Identifying risk and prognostic factors for synchronous liver metastasis in small bowel adenocarcinoma: a predictive analysis using the SEER database
Xu, Duogang
He, Yulei
Liao, Changkang
Tan, Jing
FRONTIERS IN SURGERY, 2024, 11
[25] The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
Wei, Haibin
Miao, Jia
Cui, Jianxin
Zheng, Wei
Chen, Xinpeng
Zhang, Qi
Liu, Feng
Mao, Zujie
Qiu, Songlin
Zhang, Dahong
SCIENTIFIC REPORTS, 2021, 11 (01)
[26] Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database
Liu, Qiu-Yan
Xie, Ling
Yang, Xiao-Yun
Yang, Lei
Lei, Xiao-Lin
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2022, 37 (11) : 2397 - 2407
[27] Does Small Bowel Adenocarcinoma Have a Worse Prognosis than Colonic Adenocarcinoma? A Propensity Score-matched Comparison Using the National Cancer Database
Al-Temimi, Mohammed H. H.
Waddimba, Anthony C. C.
Ogola, Gerald O. O.
Ilanga, Malynn Anne P.
Peters Jr, Walter R. R.
Fleshman Jr, James W. W.
Wells, Katerina O. O.
JOURNAL OF GASTROINTESTINAL SURGERY, 2023, 27 (08) : 1723 - 1726
[28] An Examination of Lymph Node Sampling as a Predictor of Survival in Resected Node-Negative Small Bowel Adenocarcinoma: a SEER Database Analysis
Thiessen, Maclean
Lee-Ying, R. M.
Monzon, J. G.
Tang, P. A.
JOURNAL OF GASTROINTESTINAL CANCER, 2020, 51 (01) : 280 - 288
[29] Role of Removed Lymph Nodes on the Prognosis of M0 Small-Bowel Neuroendocrine Tumors: a Propensity Score Matching Analysis from SEER Database
Xie, Jie-bin
Pang, Yue-shan
Li, Xun
Wu, Xiao-ting
JOURNAL OF GASTROINTESTINAL SURGERY, 2021, 25 (12) : 3188 - 3197
[30] Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database
May, Matthias
Aziz, Atiqullah
Zigeuner, Richard
Chromecki, Thomas
Cindolo, Luca
Schips, Luigi
De Cobelli, Ottavio
Rocco, Bernardo
De Nunzio, Cosimo
Tubaro, Andrea
Coman, Ioman
Truss, Michael
Dalpiaz, Orietta
Hoschke, Bernd
Gilfrich, Christian
Feciche, Bogdan
Stoltze, Anette
Fenske, Fabian
Fritsche, Hans-Martin
Figenshau, Robert S.
Madison, Kerry
Sanchez-Chapado, Manuel
Santiago Martin, Maria del Carmen
Salzano, Luigi
Lotrecchiano, Giuseppe
Joniau, Steven
Waidelich, Raphaela
Stief, Christian
Brookman-May, Sabine
WORLD JOURNAL OF UROLOGY, 2013, 31 (05) : 1073 - 1080

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