L-arabinose exerts probiotic functions by improving gut microbiota and metabolism in vivo and in vitro

被引:6
作者
Xiang, Shasha [1 ]
Ge, Yin [1 ]
Zhang, Yalin [2 ]
Bao, Xuan [1 ]
Su, Xiaoming [2 ]
Shi, Lihua [2 ]
Xia, Yanting [1 ]
Han, Haoying [1 ]
Ying, Jian [3 ]
Lai, Shiyun [4 ]
Chen, Jie [1 ]
Zhu, Xuan [1 ]
机构
[1] Zhejiang Gongshang Univ, Sch Food Sci & Bioengn, Hangzhou 310018, Peoples R China
[2] Hangzhou Negat Entropy Hlth Technol Co LTD, Hangzhou 310002, Peoples R China
[3] COFCO Nutr & Hlth Res Inst, Beijing 102209, Peoples R China
[4] Hangzhou Popide Sci & Tech Co Ltd, Hangzhou 310063, Peoples R China
关键词
L-arabinose; Gut microbiota; In vivo and in vitro; Linoleic acid metabolism; 12; 13-DHOME; 10-DHOME; CHAIN FATTY-ACIDS; INDUCED LIPOKINE; DIETARY FIBER; 12,13-DIHOME; FLUID;
D O I
10.1016/j.jff.2024.106047
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Prior investigations have primarily focused on the impact of L-arabinose on gut microbiota, with limited exploration into the dual mechanisms of L-arabinose on microbiota and metabolism both in vivo and in vitro. Thus, this study aimed to elucidate the anti-inflammatory effects of 5 % L-arabinose under different diet in mice. Additionally, a colon simulation system (CDMN) with utilizing 1.72 % (w/v) L-arabinose in the lumen and mucus layers, to provide further insights into the underlying mechanisms. The results revealed that L-arabinose significantly altered the gut microbiome structure, particularly elevating Bifidobacterium and short-chain fatty acids (SCFAs) both in vivo and in vitro. Subsequent in vitro experiments confirmed that L-arabinose increased the relative abundance of SCFAs-producing bacteria, facilitated linoleic acid metabolism, and enhanced downstream metabolites (12,13-DHOME, 9,10-DHOME), potentially mediated by Bifidobacterium in the descending colon. These findings underscore the role of L-arabinose in modulating intestinal flora and metabolism, thereby promoting intestinal and body health.
引用
收藏
页数:13
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