Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials

被引：1

作者：

Zhang, Lu-Kai ^{[1
,2
]}

Li, Qiang ^{[1
,2
]}

Fang, Yan-Fen ^{[1
,2
]}

Qi, Ji-Wei ^{[1
,2
,3
]}

机构：

[1] Xiaoshan Tradit Chinese Med Hosp, Dept Orthoped, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Dept Orthoped, Affiliated Jiangnan Hosp, Hangzhou, Zhejiang, Peoples R China

[3] Xiaoshan Tradit Chinese Med Hosp, Hangzhou 311201, Zhejiang, Peoples R China

来源：

MEDICINE | 2023年 / 102卷 / 10期

关键词：

analgesia; duloxetine; meta-analysis; total knee arthroplasty; SEROTONIN REUPTAKE INHIBITORS; OSTEOARTHRITIS; REPLACEMENT; SYMPTOMS; NOREPINEPHRINE; SENSITIZATION; QUALITY; HIP;

D O I：

10.1097/MD.0000000000033101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background:Postoperative pain is one of the most feared complications of total knee arthroplasty. Recently, randomized controlled trials have compared the efficacy of duloxetine in patients undergoing total knee arthroplasty. However, there is no definite answer as to the efficacy and safety of duloxetine. Methods:Randomized controlled trials about relevant studies were searched from PubMed (1996 to July 2022), Embase (1996 to July 2022), and Cochrane Library (CENTRAL, July 2022). Results:Six high-quality studies containing 532 patients met the inclusion criteria. Results show patients in the duloxetine group had better performance in terms of visual analog scale (P < .05), equivalent morphine consumption (P < .05), and length of stay (P < .05). Conclusion:Duloxetine can be used to reduce pain after knee arthroplasty in selected patients.

引用

页数：10

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