Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy

被引：5

作者：

Lv, Shimeng ^{[1
]}

Zhang, Guangheng ^{[1
]}

Huang, Yufei ^{[2
]}

Li, Jiamin ^{[1
]}

Yang, Ni ^{[1
]}

Lu, Yitong ^{[1
]}

Ma, Haoteng ^{[3
]}

Ma, Yuexiang ^{[3
]}

Teng, Jing ^{[1
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Dept Clin Med Coll 1, Jinan, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Radiol, Sch Med, Shanghai, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

关键词：

depression; autophagy; Traditional Chinese medicine; pharmacological mechanisms; antidepressant; DEPRESSION-LIKE BEHAVIOR; HIPPOCAMPAL NEUROGENESIS; SIGNALING PATHWAY; LC3; LIPIDATION; STRESS; PROTEINS; RATS; BIOGENESIS; INITIATION; PREVENTS;

D O I：

10.3389/fphar.2023.1287234

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The core symptoms of depression are anhedonia and persistent hopelessness. Selective serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for clinical treatment, despite their significant adverse effects. Traditional Chinese medicine with its multiple targets, channels, and compounds, exhibit immense potential in treating depression. Autophagy, a vital process in depression pathology, has emerged as a promising target for intervention. This review summarized the pharmacological mechanisms of antidepressants by regulating autophagy. We presented insights from recent studies, discussed current research limitations, and proposed new strategies for basic research and their clinical application in depression.

引用

页数：18

共 160 条

[71] Antidepressant efficacy of Agomelatine: Meta-analysis of placebo controlled and active comparator studies [J].

Maddukuri, Raghava Kalyan ;

Hema, Chava ;

Tejaswi, Kondaveeti Sri ;

Mounika, Mutthineni Venkata ;

Vegesana, Bindu Priyanka .

ASIAN JOURNAL OF PSYCHIATRY, 2021, 65

[72] Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects [J].

Mahar, Ian ;

Bambico, Francis Rodriguez ;

Mechawar, Naguib ;

Nobrega, Jose N. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2014, 38 :173-192

[73]

Mangan MSJ, 2018, NAT REV DRUG DISCOV, V17, P588, DOI [10.1038/nrd.2018.149, 10.1038/nrd.2018.97]

[74] Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion [J].

Martinelli, Silvia ;

Anderzhanova, Elmira A. ;

Bajaj, Thomas ;

Wiechmann, Svenja ;

Dethloff, Frederik ;

Weckmann, Katja ;

Heinz, Daniel E. ;

Ebert, Tim ;

Hartmann, Jakob ;

Geiger, Thomas M. ;

Doengi, Michael ;

Hafner, Kathrin ;

Poehlmann, Max L. ;

Jollans, Lee ;

Philipsen, Alexandra ;

Schmidt, Susanne V. ;

Schmidt, Ulrike ;

Maccarrone, Giuseppina ;

Stein, Valentin ;

Hausch, Felix ;

Turck, Christoph W. ;

Schmidt, Mathias V. ;

Gellner, Anne-Kathrin ;

Kuster, Bernhard ;

Gassen, Nils C. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[75] Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus [J].

Mendonca, Ingrid Prata ;

Rodrigues de Paiva, Igor Henrique ;

Duarte-Silva, Eduardo Pereira ;

de Melo, Michel Gomes ;

da Silva, Rodrigo S. ;

Xavier do Nascimento, Maria Isabelly ;

Peixoto, Christina Alves .

INFLAMMOPHARMACOLOGY, 2022, 30 (05) :1705-1716

[76] Vitamin E: Regulatory Redox Interactions [J].

Miyazawa, Taiki ;

Burdeos, Gregor C. ;

Itaya, Mayuko ;

Nakagawa, Kiyotaka ;

Miyazawa, Teruo .

IUBMB LIFE, 2019, 71 (04) :430-441

[77] Autophagy: Renovation of Cells and Tissues [J].

Mizushima, Noboru ;

Komatsu, Masaaki .

CELL, 2011, 147 (04) :728-741

[78] Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms [J].

Moore, Alyssa ;

Beidler, Joshua ;

Hong, Mee Young .

MOLECULES, 2018, 23 (09)

[79] Ferroptosis, a new form of cell death: opportunities and challenges in cancer [J].

Mou, Yanhua ;

Wang, Jun ;

Wu, Jinchun ;

He, Dan ;

Zhang, Chunfang ;

Duan, Chaojun ;

Li, Bin .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12

[80] Clinical application and pharmacological mechanism of Wuling powder in the treatment of ascites: A systematic review and network pharmacological analysis [J].

Mou, Yue ;

Wang, XueZhen ;

Wang, Tong ;

Wang, Yuan ;

Wang, HuaXin ;

Zhao, HaiJun ;

Chen, Qian ;

Xia, Lei ;

Zhang, YaNan .

BIOMEDICINE & PHARMACOTHERAPY, 2022, 146

← 3 4 5 6 7 8 9 10 11 12 →