Cancer/Testis Antigens as Targets for RNA-Based Anticancer Therapy

被引：7

作者：

Shim, Kyeonghee ^{[1
]}

Jo, Hyein ^{[1
]}

Jeoung, Dooil ^{[1
]}

机构：

[1] Kangwon Natl Univ, Coll Nat Sci, Dept Biochem, Chunchon 24341, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

cancer/testis antigens; clinical trials; lipid nanoparticles; RNA vaccines; RNA delivery; tumor-associated antigens; VIRUS-LIKE PARTICLES; MESSENGER-RNA; T-CELLS; TUMOR-ANTIGENS; CANCER; EXPRESSION; CYTOTOXICITY; RESISTANCE; RESPONSES; IMMUNITY;

D O I：

10.3390/ijms241914679

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the last few decades, RNA-based drugs have emerged as a promising candidate in the treatment of various diseases. The introduction of messenger RNA (mRNA) as a vaccine or therapeutic agent enables the production of almost any functional protein/peptide. The key to applying RNA therapy in clinical trials is developing safe and effective delivery systems. Exosomes and lipid nanoparticles (LNPs) have been exploited as promising vehicles for drug delivery. This review discusses the feasibility of exosomes and LNPs as vehicles for mRNA delivery. Cancer/testis antigens (CTAs) show restricted expression in normal tissues and widespread expression in cancer tissues. Many of these CTAs show expression in the sera of patients with cancers. These characteristics of CTAs make them excellent targets for cancer immunotherapy. This review summarizes the roles of CTAs in various life processes and current studies on mRNAs encoding CTAs. Clinical studies present the beneficial effects of mRNAs encoding CTAs in patients with cancers. This review highlight clinical studies employing mRNA-LNPs encoding CTAs.

引用

页数：26

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