Corticosteroids in COVID-19: pros and cons

被引：16

作者：

Bahsoun, Aymen ^{[1
]}

Fakih, Yeva ^{[1
]}

Zareef, Rana ^{[1
,2
]}

Bitar, Fadi ^{[1
,2
,3
]}

Arabi, Mariam ^{[1
,2
,3
]}

机构：

[1] Amer Univ Beirut, Fac Med, Med Ctr, Beirut, Lebanon

[2] Amer Univ Beirut, Med Ctr, Pediat Dept, Beirut, Lebanon

[3] Amer Univ Beirut, Med Ctr, Pediat Dept, Div Pediat Cardiol, Beirut, Lebanon

来源：

FRONTIERS IN MEDICINE | 2023年 / 10卷

关键词：

corticosteroids; glucocorticoids; steroids; COVID-19; SARS-CoV-2; coronavirus; GLUCOCORTICOID TREATMENT; GENE-EXPRESSION; PHARMACOLOGY; COMPLICATIONS; DEXAMETHASONE; CYTOKINE;

D O I：

10.3389/fmed.2023.1202504

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The wide and rapid spread of the COVID-19 pandemic has placed an unanticipated burden on the global healthcare sector. This necessitated a swift response from the international community to reach a solution. Efforts were made in parallel to develop preventative and therapeutic modalities. Since then, drug repurposing has blossomed as a potentially rapid resolution and has included various agents with anti-viral and anti-inflammatory properties. Corticosteroids, being potent anti-inflammatory agents, have been placed under extensive investigation. Various trials have recorded the beneficial outcome of corticosteroids in decreasing the mortality and morbidity of COVID-19. With the high pace of escalating events, the quality and study design of clinical trials are varied. Therefore, this study aims to explore the role of corticosteroids in COVID-19 disease. It inspects the molecular, pharmacologic, and clinical proof behind this theory.

引用

页数：13

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