Application of PBPK modeling in predicting maternal and fetal pharmacokinetics of levetiracetam during pregnancy

Levetiracetam is currently being used to treat epilepsy in pregnant women. The plasma concentration of leve-tiracetam drops sharply during pregnancy, and the inability of pregnant women to maintain therapeutic con-centrations can lead to seizures. This study aimed to predict the changes in fetal and maternal plasma exposure to levetiracetam during pregnancy and provide advice on dose adjustment. The physiology-based pharmacokinetics (PBPK) model was developed using PK-Sim and Mobi software, and validated following comparison of the observed plasma concentration and pharmacokinetic parameters. The levetiracetam PBPK model for mother and the fetus at various stages of pregnancy was successfully established and verified. Predictions indicated that the area under the steady-state concentration-time curve for levetiracetam decreased to 83, 62, and 67% of baseline values in the first, second, and third trimesters, respectively. Based on PBPK predictions, the recommended dose of levetiracetam is 1.2, 1.6, and 1.5 times the baseline dose in the first, second, and third trimesters, respectively, not exceeding 4000 mg/day in the third trimester due to fetal safety. The levetiracetam PBPK model for preg-nancy was successfully developed and validated, and could provide alternative levetiracetam dosing regimens across the stages of pregnancy.