The small HDL particle hypothesis of Alzheimer's disease

被引：30

作者：

Martinez, Ashley E. ^{[1
]}

Weissberger, Gali ^{[2
]}

Kuklenyik, Zsuzsanna ^{[3
]}

He, Xulei ^{[1
]}

Meuret, Cristiana ^{[1
]}

Parekh, Trusha ^{[1
]}

Rees, Jon C. ^{[3
]}

Parks, Bryan A. ^{[3
]}

Gardner, Michael S. ^{[3
]}

King, Sarah M. ^{[4
,5
]}

Collier, Timothy S. ^{[6
]}

Harrington, Michael G. ^{[7
]}

Sweeney, Melanie D. ^{[8
]}

Wang, Xinhui ^{[7
]}

Zlokovic, Berislav V. ^{[8
]}

Joe, Elizabeth ^{[7
]}

Nation, Daniel A. ^{[9
]}

Schneider, Lon S. ^{[7
,10
]}

Chui, Helena C. ^{[7
]}

Barr, John R. ^{[3
]}

Han, S. Duke ^{[11
]}

Krauss, Ronald M. ^{[4
,5
]}

Yassine, Hussein N. ^{[1
,7
]}

机构：

[1] Univ Southern Calif, Dept Med, 2250 Alcazar St Rm210, Los Angeles, CA 90089 USA

[2] Bar Ilan Univ, Interdisciplinary Dept Social Sci, Ramat Gan, Israel

[3] Ctr Dis Control & Prevent, Clin Chem Branch, Div Sci Lab, Atlanta, GA USA

[4] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[6] Cleveland HeartLab, Quest Diagnost, Cleveland, OH USA

[7] Univ Southern Calif, Dept Neurol, 2250 Alcazar St Rm210, Los Angeles, CA 90089 USA

[8] Univ Southern Calif, Zilkha Neurogenet Inst, Dept Physiol & Neurosci, Los Angeles, CA 90007 USA

[9] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Irvine, CA USA

[10] Univ Southern Calif, Dept Psychiat & Behav Sci, Los Angeles, CA 90007 USA

[11] Univ Southern Calif, Dept Family Med, Los Angeles, CA 90007 USA

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 02期

关键词：

APOE; cerebrospinal fluid; cognition; HDL; lipidomics; proteomics; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-E; CEREBROSPINAL-FLUID; AMYLOID DEPOSITION; CHOLESTEROL EFFLUX; RISK-FACTORS; LC-MS/MS; ABCA1; GENE; BRAIN;

D O I：

10.1002/alz.12649

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We propose the hypothesis that small high-density lipoprotein (HDL) particles reduce the risk of Alzheimer's disease (AD) by virtue of their capacity to exchange lipids, affecting neuronal membrane composition and vascular and synaptic functions. Concentrations of small HDLs in cerebrospinal fluid (CSF) and plasma were measured in 180 individuals >= 60 years of age using ion mobility methodology. Small HDL concentrations in CSF were positively associated with performance in three domains of cognitive function independent of apolipoprotein E (APOE) epsilon 4 status, age, sex, and years of education. Moreover, there was a significant correlation between levels of small HDLs in CSF and plasma. Further studies will be aimed at determining whether specific components of small HDL exchange across the blood, brain, and CSF barriers, and developing approaches to exploit small HDLs for therapeutic purposes.

引用

页码：391 / 404

页数：14

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