Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report

被引：1

作者：

Tomic, Kresimir ^{[1
]}

Krizanac, Dragana Karan ^{[2
]}

Skenderi, Faruk ^{[3
]}

Krpina, Kristina ^{[4
]}

Bilic, Andrea Carapina ^{[5
]}

Galic, Kristina ^{[6
]}

Gatalica, Zoran

Vranic, Semir ^{[7
]}

机构：

[1] Univ Clin Hosp Mostar, Dept Oncol, Mostar, Bosnia & Herceg

[2] Univ Clin Hosp Mostar, Dept Pathol Cytol & Forens Med, Mostar, Bosnia & Herceg

[3] Sarajevo Sch Sci & Technol, Dept Pathol, UniMed Clin, Sarajevo, Bosnia & Herceg

[4] Univ Hosp Ctr Zagreb, Clin Resp Dis Jordanovac, Zagreb, Croatia

[5] Hlth Care Ctr Mostar, Dept Family Med, Mostar, Bosnia & Herceg

[6] Univ Clin Hosp Mostar, Dept Lung Dis, Mostar, Bosnia & Herceg

[7] Qatar Univ, Coll Med, QU Hlth, Doha, Qatar

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2023年 / 45卷

关键词：

Lung cancer; Small cell lung cancer; Immunotherapy; Atezolizumab; Genomic profiling; TUMOR MUTATIONAL BURDEN; IMMUNOTHERAPY; SENSITIVITY;

D O I：

10.1016/j.rmcr.2023.101920

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of similar to three years. Comprehensive genomic profiling (CGP) of the tumor revealed high tumor mutation burden (13 mutations/Mb) and mutations of TP53, RB1 and ERCC4 genes. This case study confirms that a complete response to chemoimmunotherapy may be achieved in the case of ES-SCLC. It further provides the additional value of CGP and predictive testing in the management of ES-SCLC.

引用

页数：5

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