Recent Advances in the Synthesis of Nitrogen Heterocycles Using β-Nitrostyrenes as Substrates

被引:4
|
作者
Li, Chunmei [1 ,2 ]
Zhou, Xiang [2 ]
Zhang, Furen [2 ]
Shen, Zhenlu [1 ]
机构
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Zhejiang, Peoples R China
[2] Shaoxing Univ, Sch Chem & Chem Engn, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Zhejiang, Peoples R China
基金
美国国家科学基金会;
关键词
Drug discovery; N-heterocycles; beta-nitrostyrenes; domino reaction; green chemistry; cascade reactions; POT MULTICOMPONENT SYNTHESIS; STEREOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; REGIOSELECTIVE SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; TETRAHYDRO-4H-INDOL-4-ONE DERIVATIVES; CATALYZED CYCLIZATION; ASYMMETRIC-SYNTHESIS; OXIDATIVE AMINATION; ORGANIC FRAMEWORKS; AZOMETHINE YLIDES;
D O I
10.2174/1385272827666230329104528
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The exploration of synthetic methodologies that allow rapid access to a wide variety of N-heterocycles is of critical importance to the medicinal chemist as it provides the ability to expand the available drug-like chemical space and drives more efficient drug discovery programs. beta-Nitrostyrenes, as unique active intermediates, have been widely applied in synthetic organic chemistry because of their versatile utility as pharmaceutical agents and agrochemicals. In this review, we summarize the recent development and application of the elegant and efficient methods that enable the concise synthesis of N-heterocycles from beta-nitrostyrenes and various partners in a step- and atom-economic manner, including cascade reactions, C-H activation, regio- and stereoselective syntheses, as well as other novel syntheses, which will potentially provide useful insights for further exploring and designing novel reactions.
引用
收藏
页码:108 / 118
页数:11
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