The role of neuronal plasticity in cervical spondylotic myelopathy surgery: functional assessment and prognostic implication

被引：6

作者：

Bonosi, Lapo ^{[1
]}

Musso, Sofia ^{[1
]}

Cusimano, Luigi Maria ^{[1
]}

Porzio, Massimiliano ^{[1
]}

Giovannini, Evier Andrea ^{[1
]}

Benigno, Umberto Emanuele ^{[1
]}

Giammalva, Giuseppe Roberto ^{[1
]}

Gerardi, Rosa Maria ^{[1
]}

Brunasso, Lara ^{[1
]}

Costanzo, Roberta ^{[1
]}

Paolini, Federica ^{[1
]}

Sciortino, Andrea ^{[1
]}

Campisi, Benedetta Maria ^{[1
]}

Giardina, Kevin ^{[1
]}

Scalia, Gianluca ^{[2
]}

Iacopino, Domenico Gerardo ^{[1
]}

Maugeri, Rosario ^{[1
]}

机构：

[1] Univ Palermo, Sch Med, Dept Biomed Neurosci & Adv Diagnost, Post Grad Residency Program Neurol Surg,Neurosurg, I-90127 Palermo, Italy

[2] PO Garibaldi Nesima, ARNAS Garibaldi, Dept Neurosurg, I-95122 Catania, Italy

来源：

NEUROSURGICAL REVIEW | 2023年 / 46卷 / 01期

关键词：

Cervical myelopathy; Functional reorganization; White matter tracts; fMRI; DTI; Surgery; CONSTRAINED SPHERICAL DECONVOLUTION; TRANSCRANIAL MAGNETIC STIMULATION; DIFFUSION TENSOR TRACTOGRAPHY; ANTERIOR; DECOMPRESSION; DIAGNOSIS; RECOVERY; REORGANIZATION; SPECTROSCOPY; PREDICTION;

D O I：

10.1007/s10143-023-02062-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cervical spondylotic myelopathy (CSM) is a degenerative disease representing the most common spinal cord disorder in the adult population. It is characterized by chronic compression leading to neurological dysfunction due to static and dynamic injury of the spinal cord in cervical spine. These insidious damage mechanisms can result in the reorganization of cortical and subcortical areas. The cerebral cortex can reorganize due to spinal cord injury and may play a role in preserving neurological function. To date, the gold standard treatment of cervical myelopathy is surgery, comprising anterior, posterior, and combined approaches. However, the complex physiologic recovery processes involving cortical and subcortical neural reorganization following surgery are still inadequately understood. It has been demonstrated that diffusion MRI and functional imaging and techniques, such as transcranial magnetic stimulation (TMS) or functional magnetic resonance imaging (fMRI), can provide new insights into the diagnosis and prognosis of CSM. This review aims to shed light on the state-of-the-art regarding the pattern of cortical and subcortical areas reorganization and recovery before and after surgery in CSM patients, underlighting the critical role of neuroplasticity.

引用

页数：15

共 93 条

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