COVID-19 Therapeutics: An Update on Effective Treatments Against Infection With SARS-CoV-2 Variants

被引：6

作者：

Padasas, Bill Thaddeus ^{[1
]}

Espano, Erica ^{[1
]}

Kim, Sang-Hyun ^{[1
]}

Song, Youngcheon ^{[2
]}

Lee, Chong-Kil ^{[3
]}

Kim, Jeong-Ki ^{[1
]}

机构：

[1] Korea Univ, Dept Pharm, Coll Pharm, Sejong 30019, South Korea

[2] Sahmyook Univ, Dept Pharm, Seoul 01795, South Korea

[3] Chungbuk Natl Univ, Coll Pharm, Dept Pharmaceut, Cheongju 28644, South Korea

来源：

IMMUNE NETWORK | 2023年 / 23卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

COVID-19; Severe acute respiratory syndrome coronavirus 2; Antiviral agents; Immunotherapy; Variants; CYTOKINE STORM; FUNCTIONAL RECEPTOR; CORONAVIRUS; REMDESIVIR; REPLICATION; OUTPATIENTS; SOFOSBUVIR; INHIBITORS; ANAKINRA; PROTEIN;

D O I：

10.4110/in.2023.23.e13

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic is one of the most consequential global health crises in over a century. Since its discovery in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to mutate into different variants and sublineages, rendering previously potent treatments and vaccines ineffective. With significant strides in clinical and pharmaceutical research, different therapeutic strategies continue to be developed. The currently available treatments can be broadly classified based on their potential targets and molecular mechanisms. Antiviral agents function by disrupting different stages of SARS-CoV-2 infection, while immune-based treatments mainly act on the human inflammatory response responsible for disease severity. In this review, we discuss some of the current treatments for COVID-19, their mode of actions, and their efficacy against variants of concern. This review highlights the need to constantly evaluate COVID-19 treatment strategies to protect high risk populations and fill in the gaps left by vaccination.

引用

页数：24

共 153 条

[1] Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model [J].

Abdelnabi, Rana ;

Foo, Caroline S. ;

De Jonghe, Steven ;

Maes, Piet ;

Weynand, Birgit ;

Neyts, Johan .

JOURNAL OF INFECTIOUS DISEASES, 2021, 224 (05) :749-753

[2] Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions [J].

Abulsoud, Ahmed I. ;

El-Husseiny, Hussein M. ;

El-Husseiny, Ahmed A. ;

El-Mahdy, Hesham A. ;

Ismail, Ahmed ;

Elkhawaga, Samy Y. ;

Khidr, Emad Gamil ;

Fathi, Doaa ;

Mady, Eman A. ;

Najda, Agnieszka ;

Algahtani, Mohammad ;

Theyab, Abdulrahman ;

Alsharif, Khalaf F. ;

Albrakati, Ashraf ;

Bayram, Roula ;

Abdel-Daim, Mohamed M. ;

Doghish, Ahmed S. .

BIOMEDICINE & PHARMACOTHERAPY, 2023, 157

[3] Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach [J].

Aftab, Syed Ovais ;

Ghouri, Muhammad Zubair ;

Masood, Muhammad Umer ;

Haider, Zeshan ;

Khan, Zulqurnain ;

Ahmad, Aftab ;

Munawar, Nayla .

JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)

[4] Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance [J].

Agostini, Maria L. ;

Pruijssers, Andrea J. ;

Chappell, James D. ;

Gribble, Jennifer ;

Lu, Xiaotao ;

Andres, Erica L. ;

Bluemling, Gregory R. ;

Lockwood, Mark A. ;

Sheahan, Timothy P. ;

Sims, Amy C. ;

Natchus, Michael G. ;

Saindane, Manohar ;

Kolykhalov, Alexander A. ;

Painter, George R. ;

Baric, Ralph S. ;

Denison, Mark R. .

JOURNAL OF VIROLOGY, 2019, 93 (24)

[5] Coronavirus main proteinase (3CLpro) structure:: Basis for design of anti-SARS drugs [J].

Anand, K ;

Ziebuhr, J ;

Wadhwani, P ;

Mesters, JR ;

Hilgenfeld, R .

SCIENCE, 2003, 300 (5626) :1763-1767

[6]

Astrazeneca, AZD7442 PROVENT Phase III prophylaxis trial met primary endpoint in preventing COVID-19

[7]

Barnard Dale L., 2004, Antiviral Chemistry & Chemotherapy, V15, P15

[8] Remdesivir for the Treatment of Covid-19-Final Report [J].

Beigel, John H. ;

Tomashek, Kay M. ;

Dodd, Lori E. ;

Mehta, Aneesh K. ;

Zingman, Barry S. ;

Kalil, Andre C. ;

Hohmann, Elizabeth ;

Chu, Helen Y. ;

Luetkemeyer, Annie ;

Kline, Susan ;

de Castilla, Diego Lopez ;

Finberg, Robert W. ;

Dierberg, Kerry ;

Tapson, Victor ;

Hsieh, Lanny ;

Patterson, Thomas F. ;

Paredes, Roger ;

Sweeney, Daniel A. ;

Short, William R. ;

Touloumi, Giota ;

Lye, David Chien ;

Ohmagari, Norio ;

Oh, Myoung-don ;

Ruiz-Palacios, Guillermo M. ;

Benfield, Thomas ;

Faetkenheuer, Gerd ;

Kortepeter, Mark G. ;

Atmar, Robert L. ;

Creech, C. Buddy ;

Lundgren, Jens ;

Babiker, Abdel G. ;

Pett, Sarah ;

Neaton, James D. ;

Burgess, Timothy H. ;

Bonnett, Tyler ;

Green, Michelle ;

Makowski, Mat ;

Osinusi, Anu ;

Nayak, Seema ;

Lane, H. Clifford .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) :1813-1826

[9] Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients [J].

Bernal, A. Jayk ;

da Silva, M. M. Gomes ;

Musungaie, D. B. ;

Kovalchuk, E. ;

Gonzalez, A. ;

Delos Reyes, V ;

Martin-Quiros, A. ;

Caraco, Y. ;

Williams-Diaz, A. ;

Brown, M. L. ;

Du, J. ;

Pedley, A. ;

Assaid, C. ;

Strizki, J. ;

Grobler, J. A. ;

Shamsuddin, H. H. ;

Tipping, R. ;

Wan, H. ;

Paschke, A. ;

Butterton, J. R. ;

Johnson, M. G. ;

De Anda, C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (06) :509-520

[10] Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19 [J].

Boras, Britton ;

Jones, Rhys M. ;

Anson, Brandon J. ;

Arenson, Dan ;

Aschenbrenner, Lisa ;

Bakowski, Malina A. ;

Beutler, Nathan ;

Binder, Joseph ;

Chen, Emily ;

Eng, Heather ;

Hammond, Holly ;

Hammond, Jennifer ;

Haupt, Robert E. ;

Hoffman, Robert ;

Kadar, Eugene P. ;

Kania, Rob ;

Kimoto, Emi ;

Kirkpatrick, Melanie G. ;

Lanyon, Lorraine ;

Lendy, Emma K. ;

Lillis, Jonathan R. ;

Logue, James ;

Luthra, Suman A. ;

Ma, Chunlong ;

Mason, Stephen W. ;

McGrath, Marisa E. ;

Noell, Stephen ;

Obach, R. Scott ;

O' Brien, Matthew N. ;

O'Connor, Rebecca ;

Ogilvie, Kevin ;

Owen, Dafydd ;

Pettersson, Martin ;

Reese, Matthew R. ;

Rogers, Thomas F. ;

Rosales, Romel ;

Rossulek, Michelle I. ;

Sathish, Jean G. ;

Shirai, Norimitsu ;

Steppan, Claire ;

Ticehurst, Martyn ;

Updyke, Lawrence W. ;

Weston, Stuart ;

Zhu, Yuao ;

White, Kris M. ;

Garcia-Sastre, Adolfo ;

Wang, Jun ;

Chatterjee, Arnab K. ;

Mesecar, Andrew D. ;

Frieman, Matthew B. .

NATURE COMMUNICATIONS, 2021, 12 (01)

← 1 2 3 4 5 6 7 8 9 10 →