Molecular pathology of colorectal cancer

被引：0

作者：

Woischke, Christine ^{[1
]}

Michl, Marlies ^{[2
,3
]}

Neumann, Jens ^{[1
,4
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Pathol Inst, Med Fak, Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Med Klin & Poliklin 3, Munich, Germany

[3] Facharztpraxis Innere Med Hamatol & Onkol Tageskli, Munich, Germany

[4] Ludwig Maximilians Univ Munchen, Pathol Inst, Med Fak, Thalkirchner Str 36, D-80337 Munich, Germany

来源：

PATHOLOGIE | 2023年 / 44卷 / 05期

关键词：

Biomarkers; Liquid biopsy; Precision medicine; Proto-oncogene proteins B-raf; Microsatellite instability; FOLFIRI PLUS CETUXIMAB; KRAS MUTATION ANALYSIS; MICROSATELLITE-INSTABILITY; CLINICAL-PRACTICE; RAS MUTATIONS; BRAF; PROGNOSIS; CHEMOTHERAPY; METAANALYSIS; METASTASES;

D O I：

10.1007/s00292-023-01201-9

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In recent years, the treatment of colorectal carcinoma has experienced increasing individualization. In addition to RAS and BRAF mutational status that is firmly established in routine diagnostics, new therapeutic options evolved based on MSI and HER2 status as well as primary tumour localization. Offering the best targeted options in therapy requires new evidence-based decision-making algorithms regarding timing and scope of molecular pathological diagnostics in order for patients to receive an optimized therapy according to current treatment guidelines. New targeted therapies, some of which are about to be approved and for which pathology has to provide new molecular pathological biomarkers, will also play an increasingly important role in the future.

引用

页码：279 / 286

页数：8

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