RETRACTED: DEVELOPMENT AND OPTIMIZATION OF TPGS/P84 MIXED POLYMERIC MICELLES: ENHANCED STABILITY AND ANTICANCER EFFECT OF PACLITAXEL AGAINST TUMOR THERAPY (Retracted Article)

被引：1

作者：

Zhao, Yingli ^{[1
]}

Fang, Xing ^{[1
]}

Liu, Jianjun ^{[1
]}

Xia, Quan ^{[2
,3
]}

Tan, Chao ^{[2
,3
]}

Peng, Yao ^{[4
]}

Wu, Jingjing ^{[4
]}

Huang, Qi ^{[4
]}

机构：

[1] Second Peoples Hosp Hefei, Dept Pharm, Hefei, Anhui, Peoples R China

[2] Anhui Med Univ, Dept Pharm, Affiliated Hosp 1, Hefei, Anhui, Peoples R China

[3] State Adm Tradit Chinese Med, Grade 3 Pharmaceut Chem Lab, Hefei, Anhui, Peoples R China

[4] Anhui Med Univ, Dept Oncol, Affiliated Hosp 2, Hefei, Anhui, Peoples R China

来源：

ACTA POLONIAE PHARMACEUTICA | 2023年 / 80卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TPGS; P84; micelle; paclitaxel; tumor therapy; DRUG-DELIVERY; CANCER; NANOPARTICLES; EFFICACY; BREAST; SYSTEM;

D O I：

10.32383/appdr/161587

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mixed micelles (MMs), as a new targeted drug delivery system with high adjustability, has been widely studied in biomedicines. In order to study whether mixtures containing two different mol-ecules have an excellent targeted anti-tumor effect, MMs based on D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and triblock copolymer P84 were prepared, and the characterization, cell endo-cytosis, and exocytosis of P84/TPGS MMs were observed. Paclitaxel (PTX), a classical anti-tumor drug, was selected as a model compound to explore its anti-tumor effect in vivo. The results showed that P84/ TPGS MMs had better stability, suitably distributed particle size, good cell endocytosis, and tumor sphere permeability, which could improve the permeability of PTX in the tumor site and effectively inhibit the growth of the H22 tumor in mice. In conclusion, P84/TPGS MMs is a potential micelle carrier system of cancer targeting, needing further investigation.

引用

页码：143 / 152

页数：10

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