The synovial environment steers cartilage deterioration and regeneration

被引：26

作者：

Bolander, Johanna ^{[1
,2
]}

Brandolina, Maria Teresita Moviglia ^{[3
]}

Poehling, Gary ^{[1
,4
]}

Jochl, Olivia ^{[1
]}

Parsons, Emma ^{[1
]}

Vaughan, William ^{[1
]}

Moviglia, Gustavo ^{[1
,3
]}

Atala, Anthony ^{[1
]}

机构：

[1] Wake Forest Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC 27101 USA

[2] Katholieke Univ Leuven, Skeletal Biol & Res Engn Ctr, Leuven, Belgium

[3] Civil Assoc Res & Dev Adv Therapies ACIDTA, Buenos Aires, Argentina

[4] Wake Forest Baptist Hlth, Dept Orthopaed Surg, Winston Salem, NC USA

来源：

SCIENCE ADVANCES | 2023年 / 9卷 / 16期

基金：

比利时弗兰德研究基金会;

关键词：

MESENCHYMAL STEM-CELLS; OSTEOARTHRITIS; INJURY; INCREASE; FIBROSIS; TISSUE;

D O I：

10.1126/sciadv.ade4645

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Osteoarthritis (OA) was recently defined as an epidemic, and the lack of effective treatment is highly correlated to the limited knowledge regarding the underlying pathophysiology. Failure to regenerate upon trauma is thought to be one of the underlying causes for degenerative diseases, including OA. To investigate why lesions within an OA environment fail to heal, a heterogeneous cell population was isolated from the synovial fluid (SF) of OA patients. The cells' ability to undergo processes required for functional tissue regeneration was evaluated in the presence or absence of autologous SF. The obtained mechanistic findings were then used for the development of an immunomodulatory cell treatment, aimed to restore the pro-regenerative environment. Intra-articular injection in a clinical compassionate use study showed that the treatment restored the articular cartilage and joint homeostasis of OA patients. These findings confirm the role of pro-regenerative immune cells and their targeted influence on progenitor cells for degenerative joint disease therapies.

引用

页数：15

共 41 条

[1] Healing of a Large Long-Bone Defect through Serum-Free In Vitro Priming of Human Periosteum-Derived Cells [J].