Four sesquiterpenes isolated from Taraxacum mongolicum

被引：0

作者：

Liu, Jian-Bo ^{[1
]}

Xie, Jun ^{[1
]}

Wang, Hong-Qing ^{[1
]}

Lai, Sheng-Tian ^{[1
]}

Shao, Hong-Jie ^{[1
]}

Chen, Ruo-Yun ^{[1
]}

Kang, Jie ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 11期

关键词：

Compositae; Taraxacum mongolicum; sesquiterpene; anti-inflammatory activity; CONSTITUENTS;

D O I：

10.1080/10286020.2023.2197225

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One new sesquiterpene, (6S,7R,11S)-13-carboxy-1(10)-en-dihydroartemisinic acid (1), together with three known sesquiterpenes, ainsliaea acid B (2), mongolicumin B (3), and 11 beta,13-dihydroxydeacetylmatricarin (4) were isolated from Taraxacum mongolicum Hand.-Mazz. The structures were established on the basis of UV, IR, HR-ESI-MS, 1D and 2D NMR spectroscopy, ECD spectroscopy, and X-ray diffraction analysis. Compound 1 was found to have potential anti-inflammatory activity and could reduce LPS-induced NO levels in murine macrophage, with inhibitory rate of 37%.

引用

页码：1038 / 1043

页数：6

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