Design, Synthesis and Antimicrobial Evaluation of Novel 6-(4-Phenoxyphenyl)-2-arylpyridazin-3(2H)-one Derivatives

. The design and synthesis of selected 6-(4-phenoxyphenyl)-2-arylpyridazin-3(2H)-one derivatives (2a - f) were done and evaluated in vitro for antimicrobial activity. Synthesis of title compounds were done in 2 steps process starting from the reaction of biphenyl ether with maleic anhydride formed 4-oxo-4-(4-phenoxyphenyl) but- 2-enoic acid (1). Compound 1 was reacted with appropriate aryl hydrazines to form the title compounds (2a-f). Struc- ture of these title compounds were characterized by IR,1H-NMR,13C-NMR, and Mass spectral analysis. In in vitro antibacterial studies, compounds 2f and 2d was found to be most effective antibacterial agent against Gram positive strain S. aureus and B. cereus, and Gram negative strain E. coli and P. aeruginosa as well as antifungal agent against A. niger and A. flavus, respectively. From above results, it is concluded that in vitro results findings strengthens the research findings of these studies.