Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options

被引：14
|
作者：
Recchia, Deborah [1 ]
Stelitano, Giovanni [1 ]
Stamilla, Alessandro [1 ]
Gutierrez, Damaris L. [1 ]
Degiacomi, Giulia [1 ]
Chiarelli, Laurent R. [1 ]
Pasca, Maria Rosalia [1 ]
机构：
[1] Univ Pavia, Dept Biol & Biotechnol L Spallanzani, I-27100 Pavia, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期
关键词：
Mycobacterium abscessus; alternative strategies; nitric oxide; phage therapy; antivirulence compounds; antimicrobial peptides; phytochemicals; drug delivery; GASEOUS NITRIC-OXIDE; ANTIMICROBIAL PEPTIDES; BACTERIOPHAGES; STRATEGIES; PATHOGENS; BACTERIAL; PHAGE; TRIAL;
D O I：
10.3390/ijms24054635
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients' lungs. M. abscessus is naturally resistant to many antibiotics such as rifamycin, tetracyclines and beta-lactams. The current therapeutic regimens are not very effective and are mostly based on repurposed drugs used against Mycobacterium tuberculosis infections. Thus, new approaches and novel strategies are urgently needed. This review aims to provide an overview of the latest ongoing findings to fight M. abscessus infections by analyzing emerging and alternative treatments, novel drug delivery strategies, and innovative molecules.
引用
收藏
页数：14
相关论文
共 50 条
  • [41] New Antimicrobial Strategies to Treat Multi-Drug Resistant Infections Caused by Gram-Negatives in Cystic Fibrosis
    Scoffone, Viola Camilla
    Barbieri, Giulia
    Irudal, Samuele
    Trespidi, Gabriele
    Buroni, Silvia
    ANTIBIOTICS-BASEL, 2024, 13 (01):
  • [42] Mycobacterium abscessus infections following injection of botulinum toxin
    Fang, Rou-yu
    Sun, Qiu-ning
    JOURNAL OF COSMETIC DERMATOLOGY, 2020, 19 (04) : 817 - 819
  • [43] Mycobacterium abscessus Complex Infections: A Retrospective Cohort Study
    Sfeir, Maroun
    Walsh, Marissa
    Rosa, Rossana
    Aragon, Laura
    Liu, Sze Yan
    Cleary, Timothy
    Worley, Marylee
    Frederick, Corey
    Abbo, Lilian M.
    OPEN FORUM INFECTIOUS DISEASES, 2018, 5 (02):
  • [44] Mycobacterium abscessus infections: Epidemiology, clinical presentation and treatment
    Lerat, I.
    Truffot, C.
    Veziris, N.
    JOURNAL DES ANTI-INFECTIEUX, 2011, 13 (01) : 49 - 55
  • [45] Mycobacterium abscessus Cells Have Altered Antibiotic Tolerance and Surface Glycolipids in Artificial Cystic Fibrosis Sputum Medium
    Hunt-Serracin, Augusto Cesar
    Parks, Brian J.
    Boll, Joseph
    Boutte, Cara C.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (07)
  • [46] Molecular Epidemiological Characteristics of Mycobacterium abscessus Complex Derived from Non-Cystic Fibrosis Patients in Japan and Taiwan
    Yoshida, Mitsunori
    Chien, Jung-Yien
    Morimoto, Kozo
    Kinjo, Takeshi
    Aono, Akio
    Murase, Yoshiro
    Fujiwara, Keiji
    Morishige, Yuta
    Nagano, Hiroaki
    Jou, Ruwen
    Hasegawa, Naoki
    Ato, Manabu
    Hoshino, Yoshihiko
    Hsueh, Po-Ren
    Mitarai, Satoshi
    MICROBIOLOGY SPECTRUM, 2022, 10 (03):
  • [47] Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection
    Kim, Tae Ho
    Hanh, Bui Thi Bich
    Kim, Guehye
    Lee, Da-Gyum
    Park, June-Woo
    Lee, So Eui
    Kim, Jae-Sung
    Kim, Byoung Soo
    Ryoo, Sungweon
    Jo, Eun-Kyeong
    Jang, Jichan
    MOLECULES, 2019, 24 (24):
  • [48] Extrapulmonary infections caused by a dominant strain of Mycobacterium massiliense (Mycobacterium abscessus subspecies bolletii)
    Cheng, A.
    Liu, Y. -C.
    Chen, M. -L.
    Hung, C. -C.
    Tsai, Y. -T.
    Sheng, W. -H.
    Liao, C. -H.
    Hsueh, P. -R.
    Chen, Y. -C.
    Chang, S. -C.
    CLINICAL MICROBIOLOGY AND INFECTION, 2013, 19 (10) : E473 - E482
  • [49] THERAPEUTIC TARGETS FOR CYSTIC FIBROSIS
    Sorbera, L. A.
    Tremosa, L.
    Dulsat, C.
    DRUGS OF THE FUTURE, 2016, 41 (06) : 367 - 374
  • [50] Beyond phenotype: The genomic heterogeneity of co-infecting Mycobacterium abscessus smooth and rough colony variants in cystic fibrosis patients
    Gutierrez, Ana Victoria
    Baron, Sophie Alexandra
    Sardi, Feyrouz Sonia
    Saad, Jamal
    Coltey, Berengere
    Reynaud-Gaubert, Martine
    Drancourt, Michel
    JOURNAL OF CYSTIC FIBROSIS, 2021, 20 (03) : 421 - 423
12345