Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options

被引：14
|
作者：
Recchia, Deborah [1 ]
Stelitano, Giovanni [1 ]
Stamilla, Alessandro [1 ]
Gutierrez, Damaris L. [1 ]
Degiacomi, Giulia [1 ]
Chiarelli, Laurent R. [1 ]
Pasca, Maria Rosalia [1 ]
机构：
[1] Univ Pavia, Dept Biol & Biotechnol L Spallanzani, I-27100 Pavia, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期
关键词：
Mycobacterium abscessus; alternative strategies; nitric oxide; phage therapy; antivirulence compounds; antimicrobial peptides; phytochemicals; drug delivery; GASEOUS NITRIC-OXIDE; ANTIMICROBIAL PEPTIDES; BACTERIOPHAGES; STRATEGIES; PATHOGENS; BACTERIAL; PHAGE; TRIAL;
D O I：
10.3390/ijms24054635
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients' lungs. M. abscessus is naturally resistant to many antibiotics such as rifamycin, tetracyclines and beta-lactams. The current therapeutic regimens are not very effective and are mostly based on repurposed drugs used against Mycobacterium tuberculosis infections. Thus, new approaches and novel strategies are urgently needed. This review aims to provide an overview of the latest ongoing findings to fight M. abscessus infections by analyzing emerging and alternative treatments, novel drug delivery strategies, and innovative molecules.
引用
收藏
页数：14
相关论文
共 50 条
  • [21] Infection control strategies that successfully controlled an outbreak of Mycobacterium abscessus at a cystic fibrosis center
    Kapnadak, Siddhartha G.
    Hisert, Katherine B.
    Pottinger, Paul S.
    Limaye, Ajit P.
    Aitken, Moira L.
    AMERICAN JOURNAL OF INFECTION CONTROL, 2016, 44 (02) : 154 - 159
  • [22] Antimicrobial Properties of Basidiomycota Macrofungi to Mycobacterium abscessus Isolated from Patients with Cystic Fibrosis
    Millar, Beverley Cherie
    Nelson, David
    Moore, Rachel E.
    Rao, Juluri R.
    Moore, John E.
    INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY, 2019, 8 (01) : 93 - 97
  • [23] Environment in the lung of cystic fibrosis patients stimulates the expression of biofilm phenotype in Mycobacterium abscessus
    Keefe, Bailey F.
    Bermudez, Luiz E.
    JOURNAL OF MEDICAL MICROBIOLOGY, 2022, 71 (01)
  • [24] Cell Surface Remodeling of Mycobacterium abscessus under Cystic Fibrosis Airway Growth Conditions
    Wiersma, Crystal J.
    Belardinelli, Juan Manuel
    Avanzi, Charlotte
    Angala, Shiva Kumar
    Everall, Isobel
    Angala, Bhanupriya
    Kendall, Edward
    de Moura, Vinicius Calado Nogueira
    Verma, Deepshikha
    Benoit, Jeanne
    Brown, Karen P.
    Jones, Victoria
    Malcolm, Kenneth C.
    Strong, Michael
    Nick, Jerry A.
    Floto, R. Andres
    Parkhill, Julian
    Ordway, Diane J.
    Davidson, Rebecca M.
    McNeil, Michael R.
    Jackson, Mary
    ACS INFECTIOUS DISEASES, 2020, 6 (08): : 2143 - 2154
  • [25] Antimycobacterial activity of nonantibiotics associated with the polypharmacy of cystic fibrosis (CF) against mycobacterium abscessus
    Kirkwood, Zara, I
    Millar, Beverley C.
    Downey, Damian G.
    Moore, John E.
    INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY, 2018, 7 (04) : 358 - 360
  • [26] Molecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients
    Wetzstein, Nils
    Diricks, Margo
    Kohl, Thomas A.
    Wichelhaus, Thomas A.
    Andres, Soenke
    Paulowski, Laura
    Schwarz, Carsten
    Lewin, Astrid
    Kehrmann, Jan
    Kahl, Barbara C.
    Dichtl, Karl
    Huegel, Christian
    Eickmeier, Olaf
    Smaczny, Christina
    Schmidt, Annika
    Zimmermann, Stefan
    Naehrlich, Lutz
    Hafkemeyer, Sylvia
    Niemann, Stefan
    Maurer, Florian P.
    Hogardt, Michael
    MICROBIOLOGY SPECTRUM, 2022, 10 (04):
  • [27] Novel Therapeutic Strategies Applied to Pseudomonas aeruginosa Infections in Cystic Fibrosis
    Chirgwin, Michael E.
    Dedloff, Margaret R.
    Holban, Alina Maria
    Gestal, Monica C.
    MATERIALS, 2019, 12 (24)
  • [28] Pilot study to test inhaled nitric oxide in cystic fibrosis patients with refractory Mycobacterium abscessus lung infection
    Bentur, Lea
    Gur, Michal
    Ashkenazi, Moshe
    Livnat-Levanon, Galit
    Mizrahi, Marko
    Tal, Asher
    Ghaffari, Abdi
    Geffen, Yuval
    Aviram, Micha
    Efrati, Ori
    JOURNAL OF CYSTIC FIBROSIS, 2020, 19 (02) : 225 - 231
  • [29] Mycobacterium abscessus Complex: Natural History and Treatment Outcomes at a Tertiary Adult Cystic Fibrosis Center
    Tippett, Emma
    Ellis, Samantha
    Wilson, John
    Kotsimbos, Tom
    Spelman, Denis
    INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY, 2018, 7 (02) : 109 - 116
  • [30] Successful lung transplantation for chronic Mycobacterium abscessus infection in advanced cystic fibrosis, a case series
    Raats, Daan
    Lorent, Natalie
    Saegeman, Veroniek
    Vos, Robin
    van Ingen, Jakko
    Verleden, Geert
    Van Raemdonck, Dirk
    Dupont, Lieven
    TRANSPLANT INFECTIOUS DISEASE, 2019, 21 (02)
12345